[HTML][HTML] Potential uses of olive oil secoiridoids for the prevention and treatment of cancer: a narrative review of preclinical studies

MR Emma, G Augello, V Di Stefano, A Azzolina… - International journal of …, 2021 - mdpi.com
The Mediterranean diet (MD) is a combination of foods mainly rich in antioxidants and anti-
inflammatory nutrients that have been shown to have many health-enhancing effects. Extra …

[HTML][HTML] Targets involved in the anti-cancer activity of quercetin in breast, colorectal and liver neoplasms

A Maugeri, A Calderaro, GT Patanè, M Navarra… - International Journal of …, 2023 - mdpi.com
Phytochemicals have long been effective partners in the fight against several diseases,
including cancer. Among these, flavonoids are valuable allies for both cancer prevention …

[HTML][HTML] Oleacein attenuates lipopolysaccharide-induced inflammation in THP-1-derived macrophages by the inhibition of TLR4/MyD88/NF-κB pathway

S Cirmi, A Maugeri, C Russo, L Musumeci… - International Journal of …, 2022 - mdpi.com
It is known that plant phenolic compounds exert anti-inflammatory activity through both anti-
oxidant effects and modulation of pivotal pro-inflammatory factors. Recently, Olea europaea …

Pressurized liquid extraction optimization from supercritical defatted olive pomace: a green and selective phenolic extraction process

N Katsinas, A Bento da Silva… - ACS Sustainable …, 2021 - ACS Publications
Olive pomace (OP) is the main by-product of the olive oil industry produced in large
quantities. Its valorization as a source of phenolic bioactive compounds is paramount for the …

An updated review on the potential antineoplastic actions of oleuropein

Y Zheng, Z Liu, X Yang, L Liu… - Phytotherapy Research, 2022 - Wiley Online Library
Oleuropein is an ester of elenolic acid and hydroxytyrosol (3, 4‐dihydroxyphenylethanol). It
is a phenolic compound and the most luxuriant in olives. The detailed information related to …

[HTML][HTML] miRNA modulation and antitumor activity by the extra-virgin olive oil polyphenol oleacein in human melanoma cells

S Carpi, B Polini, C Manera, M Digiacomo… - Frontiers in …, 2020 - frontiersin.org
Extra-virgin olive oil (EVOO) polyphenols contribute to Mediterranean diet health-promoting
properties. One of the most abundant secoiridoid present in EVOO, Oleacein (OA) …

[HTML][HTML] Effects of oleacein, a new epinutraceutical bioproduct from extra virgin olive oil, in LPS-activated murine immune cells

R Muñoz-García, M Sánchez-Hidalgo, T Montoya… - Pharmaceuticals, 2022 - mdpi.com
The present study was designed to evaluate the immunomodulatory effects of the
secoiridoid from extra virgin olive oil, oleacein (OLA), deepening into the possible signaling …

[HTML][HTML] New affordable methods for large-scale isolation of major olive secoiridoids and systematic comparative study of their antiproliferative/cytotoxic effect on …

A Papakonstantinou, P Koumarianou… - International Journal of …, 2022 - mdpi.com
Olive oil phenols (OOPs) are associated with the prevention of many human cancers. Some
of these have been shown to inhibit cell proliferation and induce apoptosis. However, no …

[HTML][HTML] Oleuropein counteracts both the proliferation and migration of intra-and extragonadal seminoma cells

S Bossio, A Perri, R Malivindi, F Giordano, V Rago… - Nutrients, 2022 - mdpi.com
Recent and growing literature has reported that oleuropein (OLE), the main polyphenol in
olive leaf extract, inhibits tumor cell proliferation and reduces the invasiveness properties of …

[HTML][HTML] The SIRT2 pathway is involved in the antiproliferative effect of flavanones in human leukemia monocytic THP-1 cells

C Russo, A Maugeri, L De Luca, R Gitto, GE Lombardo… - Biomedicines, 2022 - mdpi.com
Acute myeloid leukemia (AML) represents the most alarming hematological disease for
adults. Several genetic modifications are known to be pivotal in AML; however, SIRT2 over …