The role of short-chain fatty acids in immunity, inflammation and metabolism

Y Yao, X Cai, W Fei, Y Ye, M Zhao… - Critical reviews in food …, 2022 - Taylor & Francis
Short-chain fatty acids (SCFAs) are carboxylic acids with carbon atom numbers less than 6,
which are important metabolites of gut microbiome. Existing research shows that SCFAs …

[HTML][HTML] The interaction among gut microbes, the intestinal barrier and short chain fatty acids

J Ma, X Piao, S Mahfuz, S Long, J Wang - Animal Nutrition, 2022 - Elsevier
The mammalian gut is inhabited by a massive and complicated microbial community, in
which the host achieves a stable symbiotic environment through the interdependence …

[HTML][HTML] Acetate promotes T cell effector function during glucose restriction

J Qiu, M Villa, DE Sanin, MD Buck, D O'Sullivan… - Cell reports, 2019 - cell.com
Competition for nutrients like glucose can metabolically restrict T cells and contribute to their
hyporesponsiveness during cancer. Metabolic adaptation to the surrounding …

[HTML][HTML] Short-chain fatty acid transporters: role in colonic homeostasis

S Sivaprakasam, YD Bhutia, S Yang… - Comprehensive …, 2017 - ncbi.nlm.nih.gov
Short-chain fatty acids (SCFA; acetate, propionate, and butyrate) are generated in colon by
bacterial fermentation of dietary fiber. Though diffusion in protonated form is a significant …

Ruminant nutrition symposium: role of fermentation acid absorption in the regulation of ruminal pH

JR Aschenbach, GB Penner, F Stumpff… - Journal of animal …, 2011 - academic.oup.com
Highly fermentable diets are rapidly converted to organic acids [ie, short-chain fatty acids
(SCFA) and lactic acid] within the rumen. The resulting release of protons can constitute a …

[HTML][HTML] Invited review: Role of physically effective fiber and estimation of dietary fiber adequacy in high-producing dairy cattle

Q Zebeli, JR Aschenbach, M Tafaj, J Boguhn… - Journal of dairy …, 2012 - Elsevier
Highly fermentable diets require the inclusion of adequate amounts of fiber to reduce the risk
of subacute rumen acidosis (SARA). To assess the adequacy of dietary fiber in dairy cattle …

Role of SCFAs in gut microbiome and glycolysis for colorectal cancer therapy

G Wang, Y Yu, YZ Wang, JJ Wang… - Journal of cellular …, 2019 - Wiley Online Library
Increased risk of colorectal cancer (CRC) is associated with altered intestinal microbiota as
well as short‐chain fatty acids (SCFAs) reduction of output The energy source of colon cells …

The role of transporters in the pharmacokinetics of orally administered drugs

S Shugarts, LZ Benet - Pharmaceutical research, 2009 - Springer
Drug transporters are recognized as key players in the processes of drug absorption,
distribution, metabolism, and elimination. The localization of uptake and efflux transporters …

A look at the smelly side of physiology: transport of short chain fatty acids

F Stumpff - Pflügers Archiv-European Journal of Physiology, 2018 - Springer
Fermentative organs such as the caecum, the colon, and the rumen have evolved to
produce and absorb energy rich short chain fatty acids (SCFA) from otherwise indigestible …

[HTML][HTML] Effects of forage provision to young calves on rumen fermentation and development of the gastrointestinal tract

L Castells, A Bach, A Aris, M Terré - Journal of Dairy Science, 2013 - Elsevier
Fifteen Holstein male calves were randomly assigned to 1 of 3 dietary treatments according
to age and body weight (BW) to determine the effects of feeding different forages sources on …