Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets
V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
Sepsis-associated encephalopathy and blood-brain barrier dysfunction
Q Gao, MS Hernandes - Inflammation, 2021 - Springer
Sepsis is a life-threatening clinical condition caused by a dysregulated host response to
infection. Sepsis-associated encephalopathy (SAE) is a common but poorly understood …
infection. Sepsis-associated encephalopathy (SAE) is a common but poorly understood …
[HTML][HTML] Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler
B Van Nieuwenhuyse, D Van der Linden… - Nature …, 2022 - nature.com
Post-operative bacterial infections are a leading cause of mortality and morbidity after
ongoing liver transplantation. Bacteria causing these infections in the hospital setting can …
ongoing liver transplantation. Bacteria causing these infections in the hospital setting can …
Development and external validation of a prognostic multivariable model on admission for hospitalized patients with COVID-19
J Xie, D Hungerford, H Chen, ST Abrams, S Li, G Wang… - MedRxiv, 2020 - medrxiv.org
Background COVID-19 pandemic has developed rapidly and the ability to stratify the most
vulnerable patients is vital. However, routinely used severity scoring systems are often low …
vulnerable patients is vital. However, routinely used severity scoring systems are often low …
[HTML][HTML] Inflammation and cell death of the innate and adaptive immune system during sepsis
C Nedeva - Biomolecules, 2021 - mdpi.com
Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …
or abnormal immune response to overwhelming infection. It is now widely accepted that …
[HTML][HTML] The complexity of the post-burn immune response: an overview of the associated local and systemic complications
HI Korkmaz, G Flokstra, M Waasdorp, A Pijpe… - Cells, 2023 - mdpi.com
Burn injury induces a complex inflammatory response, both locally and systemically, and is
not yet completely unravelled and understood. In order to enable the development of …
not yet completely unravelled and understood. In order to enable the development of …
[HTML][HTML] Advances in sepsis diagnosis and management: a paradigm shift towards nanotechnology
Sepsis, a dysregulated immune response due to life-threatening organ dysfunction, caused
by drug-resistant pathogens, is a major global health threat contributing to high disease …
by drug-resistant pathogens, is a major global health threat contributing to high disease …
[HTML][HTML] Epigenetic mechanisms of immune remodeling in sepsis: targeting histone modification
D Wu, Y Shi, H Zhang, C Miao - Cell death & disease, 2023 - nature.com
Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated
immune responses and multiple organ dysfunction. The imbalance between …
immune responses and multiple organ dysfunction. The imbalance between …
[HTML][HTML] IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis
RA Campbell, BK Manne, M Banerjee… - The Journal of …, 2022 - Am Soc Clin Investig
Platelets and megakaryocytes are critical players in immune responses. Recent reports
suggest infection and inflammation alter the megakaryocyte and platelet transcriptome to …
suggest infection and inflammation alter the megakaryocyte and platelet transcriptome to …
Dendritic cells in COVID-19 immunopathogenesis: insights for a possible role in determining disease outcome
RC Borges, MS Hohmann… - International Reviews of …, 2021 - Taylor & Francis
SARS-CoV-2 is the causative agent of the COVID-19 pandemic. This novel coronavirus
emerged in China, quickly spreading to more than 200 countries worldwide. Although most …
emerged in China, quickly spreading to more than 200 countries worldwide. Although most …