Mitochondria are subject to unique genetic control by both nuclear DNA and their own
genome, mitochondrial DNA (mtDNA), of which each mitochondrion contains multiple …

As one of the few cellular traits that can be quantified across the tree of life, DNA-replication
fidelity provides an excellent platform for understanding fundamental evolutionary …

Accurate estimates of virus mutation rates are important to understand the evolution of the
viruses and to combat them. However, methods of estimation are varied and often complex …

Mitochondrial DNA (mtDNA) mutations are among the most common genetic events in all
tumors and directly impact metabolic homeostasis. Despite the central role mitochondria …

Understanding why some species have more genetic diversity than others is central to the
study of ecology and evolution, and carries potentially important implications for …

Does evolution proceed faster in larger or smaller populations? The relationship between
effective population size (N e) and the rate of evolution has consequences for our ability to …

Ecological and demographic factors can significantly shape the evolution of microbial
populations both directly and indirectly, as when changes in the effective population size …

Although the human germline mutation rate is higher than that in any other well-studied
species, the rate is not exceptional once the effective genome size and effective population …

Mutation dictates the tempo and mode of evolution, and like all traits, the mutation rate is
subject to evolutionary modification. Here, we report refined estimates of the mutation rate …

The fidelity of DNA replication together with repair mechanisms ensure that the genetic
material is properly copied from one generation to another. However, on extremely rare …