Alzheimer's disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies

DS Auld, TJ Kornecook, S Bastianetto… - Progress in neurobiology, 2002 - Elsevier
Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

The cholinergic system in Alzheimer's disease

P Kása, Z Rakonczay, K Gulya - Progress in neurobiology, 1997 - Elsevier
The past decade has witnessed an enormous increase in our knowledge of the variety and
complexity of neuropathological and neurochemical changes in Alzheimer's disease …

[HTML][HTML] Strategies for the treatment of Parkinson's disease: beyond dopamine

A Iarkov, GE Barreto, JA Grizzell… - Frontiers in aging …, 2020 - frontiersin.org
Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …

Amyloid β peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures

WH Zheng, S Bastianetto, F Mennicken, W Ma, S Kar - Neuroscience, 2002 - Elsevier
The neuropathological features associated with Alzheimer's disease (AD) brain include the
presence of extracellular neuritic plaques composed of amyloid β protein (Aβ), intracellular …

Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type

A Law, S Gauthier, R Quirion - Brain research reviews, 2001 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia, with progressive cognitive
deficits being the primary symptom. AD is neuropathologically characterized by amyloid and …

Ultrasensitive detection of biomolecules with fluorescent dye-doped nanoparticles

W Lian, SA Litherland, H Badrane, W Tan, D Wu… - Analytical …, 2004 - Elsevier
Fluorescent-labeled molecules have been used extensively for a wide range of applications
in biological detection and diagnosis. A new form of highly luminescent and photostable …

Acetylcholine receptors: Key players in cancer development

J Chen, IWY Cheuk, VY Shin, A Kwong - Surgical oncology, 2019 - Elsevier
Acetylcholine (ACh) was first identified as a classic neuromodulator and transmit signals
through two subgroups of receptors, namely muscarinic receptors (mAChRs) and nicotinic …

Allosteric binding sites of Aβ peptides on the acetylcholine synthesizing enzyme ChAT as deduced by in silico molecular modeling

ATK Baidya, A Kumar, R Kumar… - International Journal of …, 2022 - mdpi.com
The native function of amyloid-β (Aβ) peptides is still unexplored. However, several recent
reports suggest a prominent role of Aβ peptides in acetylcholine homeostasis. To clarify this …

β-Amyloid peptides as direct cholinergic neuromodulators: a missing link?

DS Auld, S Kar, R Quirion - Trends in neurosciences, 1998 - cell.com
Abstract β-Amyloid peptide (Aβ) is found in diffuse and focal deposits throughout the brain
from Alzheimer's disease (AD) patients. Another feature of AD is the widespread …

Amyloid β‐peptide inhibits high‐affinity choline uptake and acetylcholine release in rat hippocampal slices

S Kar, AM Issa, D Seto, DS Auld… - Journal of …, 1998 - Wiley Online Library
The characteristic pathological features of the postmortem brain of Alzheimer's disease (AD)
patients include, among other features, the presence of neuritic plaques composed of …