Alzheimer's disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies
DS Auld, TJ Kornecook, S Bastianetto… - Progress in neurobiology, 2002 - Elsevier
Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …
characterized by progressive impairment in cognitive function during mid-to late-adult life …
The cholinergic system in Alzheimer's disease
P Kása, Z Rakonczay, K Gulya - Progress in neurobiology, 1997 - Elsevier
The past decade has witnessed an enormous increase in our knowledge of the variety and
complexity of neuropathological and neurochemical changes in Alzheimer's disease …
complexity of neuropathological and neurochemical changes in Alzheimer's disease …
[HTML][HTML] Strategies for the treatment of Parkinson's disease: beyond dopamine
Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …
Amyloid β peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures
WH Zheng, S Bastianetto, F Mennicken, W Ma, S Kar - Neuroscience, 2002 - Elsevier
The neuropathological features associated with Alzheimer's disease (AD) brain include the
presence of extracellular neuritic plaques composed of amyloid β protein (Aβ), intracellular …
presence of extracellular neuritic plaques composed of amyloid β protein (Aβ), intracellular …
Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type
A Law, S Gauthier, R Quirion - Brain research reviews, 2001 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia, with progressive cognitive
deficits being the primary symptom. AD is neuropathologically characterized by amyloid and …
deficits being the primary symptom. AD is neuropathologically characterized by amyloid and …
Ultrasensitive detection of biomolecules with fluorescent dye-doped nanoparticles
Fluorescent-labeled molecules have been used extensively for a wide range of applications
in biological detection and diagnosis. A new form of highly luminescent and photostable …
in biological detection and diagnosis. A new form of highly luminescent and photostable …
Acetylcholine receptors: Key players in cancer development
J Chen, IWY Cheuk, VY Shin, A Kwong - Surgical oncology, 2019 - Elsevier
Acetylcholine (ACh) was first identified as a classic neuromodulator and transmit signals
through two subgroups of receptors, namely muscarinic receptors (mAChRs) and nicotinic …
through two subgroups of receptors, namely muscarinic receptors (mAChRs) and nicotinic …
Allosteric binding sites of Aβ peptides on the acetylcholine synthesizing enzyme ChAT as deduced by in silico molecular modeling
ATK Baidya, A Kumar, R Kumar… - International Journal of …, 2022 - mdpi.com
The native function of amyloid-β (Aβ) peptides is still unexplored. However, several recent
reports suggest a prominent role of Aβ peptides in acetylcholine homeostasis. To clarify this …
reports suggest a prominent role of Aβ peptides in acetylcholine homeostasis. To clarify this …
β-Amyloid peptides as direct cholinergic neuromodulators: a missing link?
DS Auld, S Kar, R Quirion - Trends in neurosciences, 1998 - cell.com
Abstract β-Amyloid peptide (Aβ) is found in diffuse and focal deposits throughout the brain
from Alzheimer's disease (AD) patients. Another feature of AD is the widespread …
from Alzheimer's disease (AD) patients. Another feature of AD is the widespread …
Amyloid β‐peptide inhibits high‐affinity choline uptake and acetylcholine release in rat hippocampal slices
S Kar, AM Issa, D Seto, DS Auld… - Journal of …, 1998 - Wiley Online Library
The characteristic pathological features of the postmortem brain of Alzheimer's disease (AD)
patients include, among other features, the presence of neuritic plaques composed of …
patients include, among other features, the presence of neuritic plaques composed of …