Epidemiologic observations support the contention that infection, inflammation, and
neonatal white matter damage (WMD) are associated. We also have documentation from …

Objective The purpose of this study was to provide an updated summary of the literature
regarding the effects of tocolysis with indomethacin on neonatal outcome by systematically …

Myelin abnormalities that reflect damage to developing and mature brains are often found in
neurological diseases with evidence of inflammatory infiltration and microglial activation …

Background Axon development plays a pivotal role in the formation of synapse, nodes of
Ranvier, and myelin sheath. Interleukin-1β (IL-1β) produced by microglia may cause …

Periventricular leukomalacia (PVL), the major substrate of neurologic deficits in premature
infants, is associated with reduced white matter volume. Using immunomarkers of axonal …

Reactive microglia and astrocytes are present in lesions of white matter disorders, such as
periventricular leukomalacia and multiple sclerosis. However, it is not clear whether they are …

Objective Perinatal inflammatory responses contribute to periventricular leukomalacia (PVL)
and cerebral palsy (CP) in preterm infants. Here, we examined whether preterm children …

Periventricular leukomalacia (PVL) is the major substrate of cerebral palsy in survivors of
prematurity. Its pathogenesis is complex and likely involves ischemia/reperfusion in the …

Hypoxia–ischemia is a leading cause of morbidity and mortality in the perinatal period with
an incidence of~ 1/4000 live births. Biochemical events such as energy failure, membrane …

Newborn neurological injuries are the leading cause of intellectual and motor disabilities
that are associated with cerebral palsy. Cerebral white matter injury is a common feature in …