Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

[HTML][HTML] Diversity and versatility of p38 kinase signalling in health and disease

B Canovas, AR Nebreda - Nature reviews Molecular cell biology, 2021 - nature.com
The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …

[HTML][HTML] Signaling pathways in rheumatoid arthritis: implications for targeted therapy

Q Ding, W Hu, R Wang, Q Yang, M Zhu, M Li… - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease
progression leads to joint deformity and associated loss of function, which significantly …

Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives

Z Fang, Q Meng, J Xu, W Wang, B Zhang… - Cancer …, 2023 - Wiley Online Library
As a critical component of the tumor microenvironment (TME), cancer‐associated fibroblasts
(CAFs) play important roles in cancer initiation and progression. Well‐known signaling …

[HTML][HTML] Ribosome collisions trigger general stress responses to regulate cell fate

CCC Wu, A Peterson, B Zinshteyn, S Regot, R Green - Cell, 2020 - cell.com
Problems arising during translation of mRNAs lead to ribosome stalling and collisions that
trigger a series of quality control events. However, the global cellular response to ribosome …

The oxytocin receptor: from intracellular signaling to behavior

B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

[HTML][HTML] The p38 pathway: from biology to cancer therapy

A Martínez-Limón, M Joaquin, M Caballero… - International journal of …, 2020 - mdpi.com
The p38 MAPK pathway is well known for its role in transducing stress signals from the
environment. Many key players and regulatory mechanisms of this signaling cascade have …

[HTML][HTML] Anti-inflammatory drugs as anticancer agents

S Zappavigna, AM Cossu, A Grimaldi… - International journal of …, 2020 - mdpi.com
Inflammation is strictly associated with cancer and plays a key role in tumor development
and progression. Several epidemiological studies have demonstrated that inflammation can …

Recent advances on signaling pathways and their inhibitors in rheumatoid arthritis

S Liu, H Ma, H Zhang, C Deng, P Xin - Clinical Immunology, 2021 - Elsevier
Rheumatoid arthritis (RA) is characterized by systemic synovitis leading to joint destruction
in which imbalances in pro-inflammatory and anti-inflammatory cytokines promote the …

[HTML][HTML] Betaine in inflammation: mechanistic aspects and applications

G Zhao, F He, C Wu, P Li, N Li, J Deng, G Zhu… - Frontiers in …, 2018 - frontiersin.org
Betaine is known as trimethylglycine and is widely distributed in animals, plants, and
microorganisms. Betaine is known to function physiologically as an important …