Highlights•Patients who receive antiandrogen treatments are more likely to develop
CRPC.•A genomic landscape study has identified aberrant epigenetic events in CRPC and …

Simple Summary Although epithelial-to-mesenchymal transition (EMT) is a well-known
cellular process involved during normal embryogenesis and wound healing, it also has a …

The development of taxane resistance remains a major challenge for castration resistant
prostate cancer (CR-PCa), despite the effectiveness of taxanes in prolonging patient …

Downregulation of HLA class I (HLA-I) impairs immune recognition and surveillance in
prostate cancer and may underlie the ineffectiveness of checkpoint blockade. However, the …

Melatonin is an endogenous indoleamine with an incredible variety of properties and
activities. In recent years, an increasing number of studies have investigated this …

Ageing is characterised by a physical decline in biological functioning which results in a
progressive risk of mortality with time. As a biological phenomenon, it is underpinned by the …

Epithelial-to-mesenchymal transition (EMT) plays a vital role in the progression and
metastasis of prostate cancer. However, the molecular mechanisms underlying prostate …

Male-specific reproductive disorders and cancers have increased intensely in recent years,
making them a significant public health problem. Prostate cancer (PC) is the most often …

Among the well-established alterations contributing to prostate cancer (PCa) pathogenesis,
epigenetics is an important player in its development and aggressive disease state …

Molecular targeted therapy using poly (ADP-ribose) polymerase inhibitors has improved
survival in patients with castration-resistant prostate cancer (CRPC). However, this approach …