The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …

The glymphatic system is a network of perivascular spaces that promotes movement of
cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid …

The human stress response has evolved to maintain homeostasis under conditions of real or
perceived stress. This objective is achieved through autoregulatory neural and hormonal …

The nature of fluid dynamics within the brain parenchyma is a focus of intensive research. Of
particular relevance is its participation in diseases associated with protein accumulation and …

Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …

Epidemiological studies provided the first evidence suggesting a connection between the
circadian clock and human health. Mutant mice convincingly demonstrate the principle that …

Aging is characterized by an increased vulnerability to infection and the development of
inflammatory diseases, such as atherosclerosis, frailty, cancer and neurodegeneration …

Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and
can profoundly affect health. Accumulating evidence indicates that circadian and sleep …

All domains of life feature diverse molecular clock machineries that synchronize
physiological processes to diurnal environmental fluctuations. However, no mechanisms are …