Bispecific antibodies: from research to clinical application

J Ma, Y Mo, M Tang, J Shen, Y Qi, W Zhao… - Frontiers in …, 2021 - frontiersin.org
Bispecific antibodies (BsAbs) are antibodies with two binding sites directed at two different
antigens or two different epitopes on the same antigen. The clinical therapeutic effects of …

Rheumatoid arthritis: the impact of mental health on disease: a narrative review

MN Lwin, L Serhal, C Holroyd, CJ Edwards - Rheumatology and therapy, 2020 - Springer
Over 60% of rheumatoid arthritis (RA) patients achieve a good response after 12 months of
treatment when following the European league against rheumatism (EULAR) guidelines for …

Sinomenine inhibits the progression of rheumatoid arthritis by regulating the secretion of inflammatory cytokines and monocyte/macrophage subsets

W Liu, Y Zhang, W Zhu, C Ma, J Ruan, H Long… - Frontiers in …, 2018 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory arthropathy associated with
articular damage and attendant comorbidities. Even although RA treatment has advanced …

2018 update of the APLAR recommendations for treatment of rheumatoid arthritis

CS Lau, F Chia, L Dans, A Harrison… - … journal of rheumatic …, 2019 - Wiley Online Library
Aim To update recommendations based on current best evidence concerning the treatment
of rheumatoid arthritis (RA), focusing particularly on the role of targeted therapies, to inform …

Melatonin attenuates TNF‐α and IL‐1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis

CC Huang, CH Chiou, SC Liu, SL Hu… - Journal of pineal …, 2019 - Wiley Online Library
The hormone melatonin has many properties, including antioxidant, anti‐inflammatory, and
immunomodulatory effects. Melatonin has been demonstrated to be beneficial in several …

Treatment with biologicals in rheumatoid arthritis: an overview

P Rein, RB Mueller - Rheumatology and therapy, 2017 - Springer
Management and therapy of rheumatoid arthritis (RA) has been revolutionized by the
development and approval of the first biological disease-modifying antirheumatic drugs …

Immunological adaptations in pregnancy that modulate rheumatoid arthritis disease activity

F Förger, PM Villiger - Nature Reviews Rheumatology, 2020 - nature.com
During pregnancy, the fetus that grows within the maternal uterus is not rejected by the
maternal immune system. To enable both tolerance towards the fetus and defence against …

[HTML][HTML] State of knowledge on molecular adaptations to exercise in humans: historical perspectives and future directions

KM Lavin, PM Coen, LC Baptista, MB Bell… - Comprehensive …, 2022 - ncbi.nlm.nih.gov
For centuries, regular exercise has been acknowledged as a potent stimulus to promote,
maintain, and restore healthy functioning of nearly every physiological system of the human …

[HTML][HTML] Microneedles-based drug delivery strategies: A breakthrough approach for the management of pain

S Priya, G Singhvi - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Pain is a personalized event or body alarm system that can limit a patient's activities and
lead to negative repercussions. The commercially available conventional treatment …

An association of gut microbiota with different phenotypes in Chinese patients with rheumatoid arthritis

HI Chiang, JR Li, CC Liu, PY Liu, HH Chen… - Journal of clinical …, 2019 - mdpi.com
We aimed to investigate the association of gut microbiota with disease activity, inflammatory
parameters, and auto-antibodies profile in rheumatoid arthritis (RA). A total of 138 RA …