[HTML][HTML] The contemporary role of hematopoietic stem cell transplantation in the management of chronic myeloid leukemia: is it the same in all settings?
Simple Summary This review explores the use of hematopoietic stem cell transplantation
(HSCT) as a treatment option for chronic myeloid leukemia (CML) patients. While CML …
(HSCT) as a treatment option for chronic myeloid leukemia (CML) patients. While CML …
[HTML][HTML] Hydroxycitric acid inhibits chronic myelogenous leukemia growth through activation of AMPK and mTOR pathway
D Verrelli, L Dallera, M Stendardo, S Monzani… - Nutrients, 2022 - mdpi.com
Metabolic regulation of cancer cell growth via AMP-activated protein kinase (AMPK)
activation is a widely studied strategy for cancer treatment, including leukemias. Recent …
activation is a widely studied strategy for cancer treatment, including leukemias. Recent …
Trial Watch: combination of tyrosine kinase inhibitors (TKIs) and immunotherapy
A Petrazzuolo, MC Maiuri, L Zitvogel, G Kroemer… - …, 2022 - Taylor & Francis
The past decades witnessed the clinical employment of targeted therapies including but not
limited to tyrosine kinase inhibitors (TKIs) that restrain a broad variety of pro-tumorigenic …
limited to tyrosine kinase inhibitors (TKIs) that restrain a broad variety of pro-tumorigenic …
[HTML][HTML] Study of the intestinal microbiota composition and the effect of treatment with intensive chemotherapy in patients recovered from acute leukemia
X Vázquez, P Lumbreras-Iglesias, MR Rodicio… - Scientific Reports, 2024 - nature.com
A dataset comprising metagenomes of outpatients (n= 28) with acute leukemia (AL) and
healthy controls (n= 14) was analysed to investigate the associations between gut …
healthy controls (n= 14) was analysed to investigate the associations between gut …
Mutational landscape of chronic myeloid leukemia: more than a single oncogene leukemia
S Adnan-Awad, M Kankainen, S Mustjoki - Leukemia & lymphoma, 2021 - Taylor & Francis
The BCR-ABL1 fusion gene, which causes aberrant kinase activity and uncontrolled cell
proliferation, is the hallmark of chronic myeloid leukemia (CML). The development of …
proliferation, is the hallmark of chronic myeloid leukemia (CML). The development of …
A machine learning model to successfully predict future diagnosis of chronic myelogenous leukemia with retrospective electronic health records data
Background Chronic myelogenous leukemia (CML) is a clonal stem cell disorder accounting
for 15% of adult leukemias. We aimed to determine if machine learning models could predict …
for 15% of adult leukemias. We aimed to determine if machine learning models could predict …
Cell-penetrating peptide and cationic liposomes mediated siRNA delivery to arrest growth of chronic myeloid leukemia cells in vitro
V Vysochinskaya, Y Zabrodskaya, O Dovbysh… - Biochimie, 2024 - Elsevier
Gene silencing through RNA interference (RNAi) is a promising therapeutic approach for a
wide range of disorders, including cancer. Non-viral gene therapy, using specific siRNAs …
wide range of disorders, including cancer. Non-viral gene therapy, using specific siRNAs …
[HTML][HTML] The Role of N6-Methyladenosine (m6A) Methylation Modifications in Hematological Malignancies
Y Zhao, H Peng - Cancers, 2022 - mdpi.com
Simple Summary Recently, despite the common application of various novel therapies (eg,
immunotherapy and stem cell transplantation) in hematologic tumors, hematologic …
immunotherapy and stem cell transplantation) in hematologic tumors, hematologic …
[HTML][HTML] A review on the therapeutic role of TKIs in case of CML in combination with epigenetic drugs
M Amir, S Javed - Frontiers in genetics, 2021 - frontiersin.org
Chronic myeloid leukemia is a malignancy of bone marrow that affects white blood cells.
There is strong evidence that disease progression, treatment responses, and overall clinical …
There is strong evidence that disease progression, treatment responses, and overall clinical …
[HTML][HTML] CML derived exosomes promote tumor favorable functional performance in T cells
N Jafarzadeh, MA Gholampour, MR Alivand, S Kavousi… - BMC cancer, 2021 - Springer
Background Leukemic cells facilitate the creation of the tumor-favorable microenvironment
in the bone marrow niche using their secreted factors. There are not comprehensive details …
in the bone marrow niche using their secreted factors. There are not comprehensive details …