Technology of deep brain stimulation: current status and future directions

JK Krauss, N Lipsman, T Aziz, A Boutet… - Nature Reviews …, 2021 - nature.com
Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based
neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and …

Towards network-guided neuromodulation for epilepsy

RJ Piper, RM Richardson, G Worrell, DW Carmichael… - Brain, 2022 - academic.oup.com
Epilepsy is well-recognized as a disorder of brain networks. There is a growing body of
research to identify critical nodes within dynamic epileptic networks with the aim to target …

[HTML][HTML] Predicting optimal deep brain stimulation parameters for Parkinson's disease using functional MRI and machine learning

A Boutet, R Madhavan, GJB Elias, SE Joel… - Nature …, 2021 - nature.com
Commonly used for Parkinson's disease (PD), deep brain stimulation (DBS) produces
marked clinical benefits when optimized. However, assessing the large number of possible …

[HTML][HTML] Lead-DBS v3. 0: Mapping deep brain stimulation effects to local anatomy and global networks

C Neudorfer, K Butenko, S Oxenford, N Rajamani… - Neuroimage, 2023 - Elsevier
Following its introduction in 2014 and with support of a broad international community, the
open-source toolbox Lead-DBS has evolved into a comprehensive neuroimaging platform …

Personalized connectivity‐guided DLPFC‐TMS for depression: Advancing computational feasibility, precision and reproducibility

RFH Cash, L Cocchi, J Lv, Y Wu… - Human brain …, 2021 - Wiley Online Library
Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex
(DLPFC) is an established treatment for refractory depression, however, therapeutic …

[HTML][HTML] Opportunities of connectomic neuromodulation

A Horn, MD Fox - Neuroimage, 2020 - Elsevier
The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …

[HTML][HTML] Insights and opportunities for deep brain stimulation as a brain circuit intervention

WJ Neumann, A Horn, AA Kühn - Trends in Neurosciences, 2023 - cell.com
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …

Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions

WJ Neumann, LA Steiner, L Milosevic - Brain, 2023 - academic.oup.com
Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …

Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia

A Horn, MM Reich, S Ewert, N Li… - Proceedings of the …, 2022 - National Acad Sciences
Dystonia is a debilitating disease with few treatment options. One effective option is deep
brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of …

Toward personalized medicine in connectomic deep brain stimulation

B Hollunder, N Rajamani, SH Siddiqi, C Finke… - Progress in …, 2022 - Elsevier
At the group-level, deep brain stimulation leads to significant therapeutic benefit in a
multitude of neurological and neuropsychiatric disorders. At the single-patient level …