Metabolic phenotype of bladder cancer

F Massari, C Ciccarese, M Santoni, R Iacovelli… - Cancer treatment …, 2016 - Elsevier
Metabolism of bladder cancer represents a key issue for cancer research. Several metabolic
altered pathways are involved in bladder tumorigenesis, representing therefore interesting …

Emerging antibody-based therapeutic strategies for bladder cancer: A systematic review

R Azevedo, JA Ferreira, A Peixoto, M Neves… - Journal of controlled …, 2015 - Elsevier
Bladder cancer is the most common malignancy of the urinary tract, presents the highest
recurrence rate among solid tumors and is the second leading cause of death in …

Abnormal protein glycosylation and activated PI3K/Akt/mTOR pathway: role in bladder cancer prognosis and targeted therapeutics

C Costa, S Pereira, L Lima, A Peixoto, E Fernandes… - PLoS …, 2015 - journals.plos.org
Muscle invasive bladder cancer (MIBC, stage≥ T2) is generally associated with poor
prognosis, constituting the second most common cause of death among genitourinary …

Cancer stem cells and epithelial–mesenchymal transition in urothelial carcinoma: Possible pathways and potential therapeutic approaches

D Fang, H Kitamura - International Journal of Urology, 2018 - Wiley Online Library
There is growing evidence of the presence of cancer stem cells in urothelial carcinoma.
Cancer stem cells have the ability to self‐renew and to differentiate into all cell types of the …

Urothelial cancer stem cells and epithelial plasticity: current concepts and therapeutic implications in bladder cancer

M Garg - Cancer and Metastasis Reviews, 2015 - Springer
Urothelial carcinoma is a highly heterogeneous disease that develops along two distinct
biological tracks as evident by candidate gene analysis and genome-wide screening and …

Chronic inflammation in urothelial bladder cancer

G Nesi, S Nobili, T Cai, S Caini, R Santi - Virchows Archiv, 2015 - Springer
The association between inflammation and cancer has been pointed out in epidemiological
and clinical studies, revealing how chronic inflammation may contribute to carcinogenesis in …

Bladder cancer stem-like cells: their origin and therapeutic perspectives

T Ohishi, F Koga, T Migita - International journal of molecular sciences, 2015 - mdpi.com
Bladder cancer (BC), the most common cancer arising from the human urinary tract, consists
of two major clinicopathological phenotypes: muscle-invasive bladder cancer (MIBC) and …

Stem-like signature predicting disease progression in early stage bladder cancer. The role of E2F3 and SOX4

J Bellmunt - Biomedicines, 2018 - mdpi.com
The rapid development of the cancer stem cells (CSC) field, together with powerful genome-
wide screening techniques, have provided the basis for the development of future alternative …

Key role of obesity in genitourinary tumors with emphasis on urothelial and prostate cancers

M Santoni, A Cimadamore, F Massari, F Piva, G Aurilio… - Cancers, 2019 - mdpi.com
Background: In human populations, a certain amount of data correlate obesity/body mass
index (BMI) with urothelial cancer (UC) and prostate cancer (PCa) occurrence, however this …

The new age of-omics in urothelial cancer–re-wording its diagnosis and treatment

T Katsila, M Liontos, GP Patrinos, A Bamias… - …, 2018 - thelancet.com
Unmet needs in urothelial cancer management represent an important challenge in our
effort to improve long-term overall and disease-free survival rates with no significant …