Deposits of amyloid β-protein (Aβ) in neuritic plaques and cerebral vessels are a
pathological hallmark of Alzheimer's disease. Fibrillar Aβ deposits are closely associated …

The earliest event so far known that occurs in the brain affected with Alzheimer's disease
(AD) is the deposition and fibril formation of amyloid β–protein (Aβ). Aβ is cleaved from a …

The three-dimensional solution structure of the 40 residue amyloid β-peptide, Aβ (1− 40),
has been determined using NMR spectroscopy at pH 5.1, in aqueous sodium dodecyl …

Alzheimer's disease (AD) is the most prominent neurodegenerative disorder in the aging
population. It is characterized by cognitive decline, gradual neurodegeneration, and the …

Many neurodegenerative diseases are characterized by the accumulation of abnormal
protein aggregates in the brain. In Parkinson's disease (PD), α-synuclein (α-syn) forms such …

The effort to decipher the mechanism of Alzheimer's disease (AD) 1 has attracted the interest
of investigators from diverse biological disciplines, including biochemistry, cell biology …

THE protease inhibitor α,-antichymotrypsin and the lipid transport protein apolipoprotein E
(apoE) are intimately associated with the 42-amino-acid β-peptide (Aβ) in the filamentous …

Alzheimer's disease (AD) is an age-related progressive neurodegenerative disease
affecting thousands of people in the world and effective treatment is still not available. Over …

While prevailing evidence supports that the amyloid cascade hypothesis is a key component
of Alzheimer's disease (AD) pathology, many recent studies indicate that the vascular …

The amyloid-β peptide Aβ42 is known to be a primary amyloidogenic and pathogenic agent
in Alzheimer's disease. However, the role of Aβ43, which is found just as frequently in the …