The entorhinal-hippocampal system contains distinct networks subserving declarative
memory. This system is selectively vulnerable to changes of ageing and pathological …

Mutations in the β-amyloid precursor protein are strongly associated with some cases of
familial Alzheimer's disease. The normal physiological role of β-amyloid precursor protein in …

Increasing evidence points to synaptic plasticity impairment as one of the first events in
Alzheimer's disease (AD). However, studies on synaptic dysfunction in different transgenic …

Alzheimer's disease (AD) is characterized by the accumulation of cerebral plaques
composed of 40-and 42-amino acid β-amyloid (Aβ) peptides, and autosomal dominant forms …

Background: To simultaneously study several biomarkers for Alzheimer disease (AD), we
used the xMAP™ technology to develop and evaluate a multiparametric bead-based assay …

Traumatic brain injury (TBI) is a risk factor for the development of Alzheimer's disease (AD).
This immunohistochemical study determined the extent of AD-related changes in temporal …

Missense mutations in the presenilin 1 (PS1) gene cause the most common form of
dominant early–onset familial Alzheimer's disease (FAD) 1, 2 and are associated with …

Alzheimer's disease (AD) is hypothesized to be caused by an overproduction or reduced
clearance of amyloid-β (Aβ) peptide. Autosomal dominant AD (ADAD) caused by mutations …

The abnormal accumulation of amyloid‐β (Aβ) peptide in the brain is one of the most
important hallmarks of Alzheimer's disease. Aβ is an aggregation‐prone and toxic …

The equilibrium of metal ions is critical for many physiological functions, particularly in the
central nervous system, where metals are essential for development and maintenance of …