Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

The increasing of intracellular calcium concentration is a fundamental process for mediating
osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium …

Cancerous cells can originate in a number of different tissues such as prostate, breast and
lung, but often go undetected and are non-painful. Many types of cancers have a propensity …

Colorectal cancer is the third leading cause of cancer incidence and mortality in the United
States. Cannabidiol (CBD), the second most abundant phytocannabinoid in Cannabis …

Osteoarthritis (OA) is a disease of the joints that affects several million individuals worldwide.
This disease, which involves mainly the diarthrodial joints, is chronic and develops slowly …

Bone grafts are one of the most commonly transplanted tissues. However, autologous grafts
are in short supply, and can be associated with pain and donor-site morbidity. The creation …

Bone is a dynamic tissue, whose homeostasis is maintained by a fine balance between
osteoclast (OC) and osteoblast (OB) activity. The endocannabinoid/endovanilloid (EC/EV) …

Objective To assess if a coding variant in the gene encoding transient receptor potential
cation channel, subfamily V, member 1 (TRPV1) is associated with genetic risk of painful …

The cannabinoid system is ubiquitously present and is classically considered to engage in
neural and immunity processes. Yet, the role of the cannabinoid system in the whole body …

The pathogenesis of bone resorption in β-thalassemia major is multifactorial and our
understanding of the underlying molecular and cellular mechanisms remains incomplete …