Tumor cells reside in a highly complex and heterogeneous tumor microenvironment (TME),
which is composed of a myriad of genetically stable non-cancer cells, including fibroblasts …

BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …

Most of the drugs and pharmacologically relevant molecules possess heterocyclic ring
structures and presence of hetero atoms or groupings divulges privileged specificities in …

Pancreatic ductal adenocarcinoma (PDA) remains one of the deadliest forms of cancer, in
part, because it is largely refractory to current therapies. The failure of most standard …

Abstract SARS-CoV-2 (2019-nCoV) is the pathogenic coronavirus responsible for the global
pandemic of COVID-19 disease. The Spike (S) protein of SARS-CoV-2 attaches to host lung …

Cancer cells show a formidable capacity to survive under stringent conditions, to elude
mechanisms of control, such as apoptosis, and to resist therapy. Cancer cells reprogram …

Aminoacyl-tRNA synthetases (AARSs) are the enzymes that catalyze the aminoacylation
reaction by covalently linking an amino acid to its cognate tRNA in the first step of protein …

Mortality and morbidity in patients with solid tumors invariably result from the disruption of
normal biological function caused by disseminating tumor cells. Tumor cell migration is …

Most tumors develop abnormal fibrotic regions consisting of fibroblasts, immune cells, and a
dense extracellular matrix (ECM) immersed in a viscous interstitial fluid, and an abundant …

Febrifugine is the active component of the Chinese herb Chang Shan (Dichroa febrifuga
Lour.),, which has been used for treating malaria-induced fever for about 2,000 years …