As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a novel epidemic
strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus …

Drug transporter proteins are critical to the distribution of a wide range of endogenous
compounds and xenobiotics such as hormones, bile acids, peptides, lipids, sugars, and …

The use of biologics (peptide and protein based drugs) has increased significantly over the
past few decades. However, their development has been limited by their short half-life …

Conspectus The structural boundaries of living cells are composed of numerous membrane-
forming lipids. Lipids not only are crucial for the cellular compartmentalization but also are …

The glucagon-like peptide-1 receptor (GLP-1R), a key pharmacological target in type 2
diabetes (T2D) and obesity, undergoes rapid endocytosis after stimulation by endogenous …

Post-translational modifications (PTMs) endow proteins with new properties to respond to
environmental changes or growth needs. With the development of advanced proteomics …

Cognizance of the nano–bio interaction further bolsters cancer nanomedicine. Accentuating
it, we have unveiled the potential therapeutic role of a cobalt nanoparticle (Co NP), the …

S-Fatty-acylation is the covalent attachment of long chain fatty acids, predominately
palmitate (C16: 0, S-palmitoylation), to cysteine (Cys) residues via a thioester linkage on …