The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …

Human and animal studies have converged to suggest that caffeine consumption prevents
memory deficits in aging and Alzheimer's disease through the antagonism of adenosine A …

Dysfunction of goal-directed behaviors under stressful or pathological conditions results in
impaired decision-making and loss of flexibility of thoughts and behaviors, which underlie …

Adenosine A 2A receptors are putative therapeutic targets for neurological disorders. The
adenosine A 2A receptor antagonist istradefylline is approved in Japan for Parkinson's …

Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in
increased adenosine release, thereby constraining excessive excitation. The exceptionally …

Adenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure
activity produces large quantities of adenosine, and it is this seizure-induced adenosine …

The glymphatic-lymphatic system is increasingly recognized as fundamental for the
homeostasis of the brain milieu since it defines cerebral spinal fluid flow in the brain …

The consumption of caffeine modulates working and reference memory through the
antagonism of adenosine A 2A receptors (A 2A Rs) controlling synaptic plasticity processes …

Cognitive impairments in Huntington's disease (HD) are attributed to a dysfunction of the
cortico-striatal pathway and significantly affect the quality of life of the patients, but this has …