Experience-dependent flexibility in a molecularly diverse central-to-peripheral auditory feedback system

MM Frank, AA Sitko, K Suthakar, LT Cadenas, M Hunt… - Elife, 2023 - elifesciences.org
Brainstem olivocochlear neurons (OCNs) modulate the earliest stages of auditory
processing through feedback projections to the cochlea and have been shown to influence …

Signal processing and stimulation potential within the ascending auditory pathway: a review

AE Quimby, K Wei, D Adewole, S Eliades… - Frontiers in …, 2023 - frontiersin.org
The human auditory system encodes sound with a high degree of temporal and spectral
resolution. When hearing fails, existing neuroprosthetics such as cochlear implants may …

Cholinergic modulation in the vertebrate auditory pathway

C Zhang, RM Burger - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
Acetylcholine (ACh) is a prevalent neurotransmitter throughout the nervous system. In the
brain, ACh is widely regarded as a potent neuromodulator. In neurons, ACh signals are …

Auditory brainstem mechanisms likely compensate for self-imposed peripheral inhibition

S Boothalingam, A Peterson, L Powell, V Easwar - Scientific Reports, 2023 - nature.com
Feedback networks in the brain regulate downstream auditory function as peripheral as the
cochlea. However, the upstream neural consequences of this peripheral regulation are less …

Characterization of three cholinergic inputs to the cochlear nucleus

NL Beebe, YN Herrera, WA Noftz, MT Roberts… - Journal of Chemical …, 2023 - Elsevier
Acetylcholine modulates responses throughout the auditory system, including at the earliest
brain level, the cochlear nucleus (CN). Previous studies have shown multiple sources of …

An inhibitory glycinergic projection from the cochlear nucleus to the lateral superior olive

DJ Weingarten, E Sebastian, J Winkelhoff… - Frontiers in Neural …, 2023 - frontiersin.org
Auditory brainstem neurons in the lateral superior olive (LSO) receive excitatory input from
the ipsilateral cochlear nucleus (CN) and inhibitory transmission from the contralateral CN …

Electrical signaling in cochlear efferents is driven by an intrinsic neuronal oscillator

H Hong, D Zeppenfeld… - Proceedings of the …, 2022 - National Acad Sciences
Efferent neurons are believed to play essential roles in maintaining auditory function. The
lateral olivocochlear (LOC) neurons—which project from the brainstem to the inner ear …

Molecular and functional profiling of cell diversity and identity in the lateral superior olive, an auditory brainstem center with ascending and descending projections

A Maraslioglu-Sperber, E Pizzi, JO Fisch… - Frontiers in Cellular …, 2024 - frontiersin.org
The lateral superior olive (LSO), a prominent integration center in the auditory brainstem,
contains a remarkably heterogeneous population of neurons. Ascending neurons …

Neural Fluctuation Contrast as a Code for Complex Sounds: The Role and Control of Peripheral Nonlinearities

LH Carney - Hearing Research, 2024 - Elsevier
The nonlinearities of the inner ear are often considered to be obstacles that the central
nervous system has to overcome to decode neural responses to sounds. This review …

[HTML][HTML] Candidate Key Proteins in Tinnitus—A Bioinformatic Study of Synaptic Transmission in the Cochlear Nucleus

J Gross, M Knipper, B Mazurek - Biomedicines, 2024 - ncbi.nlm.nih.gov
The aim of this study was to identify key proteins of synaptic transmission in the cochlear
nucleus (CN) that are involved in normal hearing, acoustic stimulation, and tinnitus. A gene …