Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis and
emphysema. Environmental exposure, primarily cigarette smoking, can cause high oxidative …

Significance: The mitochondrial antioxidant manganese superoxide dismutase (MnSOD) is
encoded by genomic DNA and its dismutase function is fully activated in the mitochondria to …

Although oxygen is a prerequisite to life, at concentrations beyond the physiological limits it
may be hazardous to the cells. Since the lungs are directly exposed to very high amounts of …

The lungs are directly exposed to higher oxygen concentrations than most other tissues.
Increased oxidative stress is a significant part of the pathogenesis of obstructive lung …

The cellular oxidation and reduction (redox) environment is influenced by the production
and removal of reactive oxygen species (ROS). In recent years, several reports support the …

Reactive oxygen metabolites have multifactorial effects on the regulation of cell growth and
the capacity of malignant cells to invade. Overexpression of the superoxide dismutases …

Oxygen (O2) is life essential but as a drug has a maximum positive biological benefit and
accompanying toxicity effects. Oxygen is therapeutic for treatment of hypoxemia and hypoxia …

Acute respiratory distress syndrome (ARDS) usually requires symptomatic supportive
therapy by intubation and mechanical ventilation with the supplemental use of high oxygen …

Oxidative stress has been linked to various disease states as well as physiological aging.
The lungs are uniquely exposed to a highly oxidizing environment and have evolved several …

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. Many biological …