Investigation of novel benzoxazole-oxadiazole derivatives as effective anti-Alzheimer's agents: in vitro and in silico approaches
Alzheimer's disease (AD) is a progressive neurological illness that is distinguished clinically
by cognitive and memory decline and adversely affects the people of old age. The …
by cognitive and memory decline and adversely affects the people of old age. The …
Current pharmacophore based approaches for the development of new anti-Alzheimer's agents
Amyloid beta peptide (Aβ) and hyperphosphorylated neuronal tau proteins accumulate in
neurofibrillary tangles in Alzheimer's disease (AD), a chronic neurodegenerative illness …
neurofibrillary tangles in Alzheimer's disease (AD), a chronic neurodegenerative illness …
Molecular modeling, synthesis, and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activities of novel benzimidazole-bearing thiadiazole derivatives
A new series of benzimidazole-based thiadiazole hybrids analogues (6a–p) as effective
Alzheimer's inhibitors were synthesized and then evaluated for their inhibition profile against …
Alzheimer's inhibitors were synthesized and then evaluated for their inhibition profile against …
Discovery of blood-brain barrier permeable and orally bioavailable caffeine-based amide derivatives as acetylcholinesterase inhibitors
Caffeine is one of the privileged natural products that shows numerous effects on the central
nervous system. Herein, thirty-one caffeine-based amide derivatives were synthesized and …
nervous system. Herein, thirty-one caffeine-based amide derivatives were synthesized and …
Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy
The development of multitargeted therapeutics has evolved as a promising strategy to
identify efficient therapeutics for neurological disorders. We report herein new quinolinone …
identify efficient therapeutics for neurological disorders. We report herein new quinolinone …
Hypericum perforatum L. Nanoemulsion Mitigates Cisplatin-Induced Chemobrain via Reducing Neurobehavioral Alterations, Oxidative Stress, Neuroinflammation …
HMA Khalil, HMA El Henafy, IA Khalil, AF Bakr… - Toxics, 2023 - mdpi.com
Cisplatin (Cis) is a potent chemotherapeutic agent; however, it is linked with oxidative stress,
inflammation, and apoptosis, which may harmfully affect the brain. Hypericum perforatum …
inflammation, and apoptosis, which may harmfully affect the brain. Hypericum perforatum …
Exploring target site interactions of 1, 3, 4-Oxadiazole/1, 3, 4-thiadiazole derivatives: Synthesis, characterization in vitro anti-urease and in silico molecular docking …
Urease enzyme is one of the major causes of severe health issues including urinary catheter
encrustation, gastric cancer, duodenal ulcer and peptic ulcer. In search for potent anti …
encrustation, gastric cancer, duodenal ulcer and peptic ulcer. In search for potent anti …
Design, Synthesis, and Herbicidal Activity of Novel Tetrahydrophthalimide Derivatives Containing Oxadiazole/Thiadiazole Moieties
W Geng, Q Zhang, L Liu, G Tai… - Journal of Agricultural and …, 2024 - ACS Publications
Protoporphyrinogen oxidase (PPO, EC 1.3. 3.4) has a high status in the development of new
inhibitors. To develop novel and highly effective PPO inhibitors, active substructure linking …
inhibitors. To develop novel and highly effective PPO inhibitors, active substructure linking …
Biomolecular Screening of Pimpinella anisum L. for Antioxidant and Anticholinesterase Activity in Mice Brain
Hundreds of the plants have been explored and evaluated for antioxidant and anti-amnesic
activities, so far. This study was designed to report the biomolecules of Pimpinella anisum L …
activities, so far. This study was designed to report the biomolecules of Pimpinella anisum L …
Structure-Guided Design, Synthesis, and Biological Evaluation of Peripheral Anionic Site Selective and Brain Permeable Novel Oxadiazole-Piperazine Conjugates …
Alzheimer's disease (AD) is a multifactorial and emerging neurological disorder, which has
invoked researchers to develop multitargeted ligands. Herein, hybrid conjugates of 5-phenyl …
invoked researchers to develop multitargeted ligands. Herein, hybrid conjugates of 5-phenyl …