Modern interest in muscarinic acetylcholine receptor (mAChR) activators for schizophrenia
began in the 1990s when xanomeline, an M 1/M 4-preferring mAChR agonist developed for …

Animal models are indispensable tools in the search to identify new antidepressant drugs
and to provide insights into the neuropathology that underlies the idiopathic disease state of …

Background Aging is considered to be associated with progressive changes in the brain and
its associated sensory, motor, and cognitive functions. A large number of studies comparing …

We evolved muscarinic receptors in yeast to generate a family of G protein-coupled
receptors (GPCRs) that are activated solely by a pharmacologically inert drug-like and …

Although the mouse genome is now completely sequenced, the functions of most of the
genes expressed in the brain are not known. The influence of a given gene on a specific …

Environmental temperature is thought to be directly sensed by neurons through their
projections in the skin. A subset of the mammalian transient receptor potential (TRP) family …

The ability to modify mice genetically has been one of the major breakthroughs in modern
medical science affecting every discipline including psychiatry. It is hoped that the …

Muscarinic acetylcholine receptors (mAChRs), M1–M5, regulate the activity of numerous
fundamental central and peripheral functions. The lack of small-molecule ligands that can …

Abstract The endosome-associated GTPase Rab5 is a central player in the molecular
mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
progressive deterioration of cognitive functions. The pathological hallmarks are extracellular …