Rodents (especially Mus musculus and Rattus norvegicus) have been the most widely used
models in biomedical research for many years. A notable shift has taken place over the last …

The selective 5-HT2C receptor agonist lorcaserin, in conjunction with lifestyle modification,
was approved by the FDA in 2012 for weight management. It has been marketed in the US …

Impulsivity, defined as impaired decision making, is associated with many psychiatric and
behavioral disorders, such as attention-deficit/hyperactivity disorder as well as eating …

Long term benefits following short-term administration of high psychedelic doses of
serotonergic and dissociative hallucinogens, typified by psilocybin and ketamine …

Calcium imaging using GCaMP indicators and miniature microscopes has been used to
image cellular populations during long timescales and in different task phases, as well as to …

Abstract Background The nucleus accumbens (NAc) controls multiple facets of impulsivity
but is a heterogeneous brain region with diverse microcircuitry. Prior literature links …

This article reviews recent advances in the elucidation of neurobehavioral endophenotypes
associated with drug addiction made possible by the translational neuroimaging techniques …

Currently, about 246 million people around the world have used an illicit drug. The reasons
for this use are multiple: eg to augment the sensation of pleasure or to reduce the withdrawal …

A feature of multiple neuropsychiatric disorders is motor impulsivity. Recent studies have
implicated serotonin (5-HT) systems in medial prefrontal cortex (mPFC) in mediating …

To identify addiction genes, we evaluate intravenous self-administration of cocaine or saline
in 84 inbred and recombinant inbred mouse strains over 10 days. We integrate the behavior …