[HTML][HTML] What is a cell type and how to define it?

H Zeng - Cell, 2022 - cell.com
Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

Two-photon calcium imaging of neuronal activity

C Grienberger, A Giovannucci, W Zeiger… - Nature Reviews …, 2022 - nature.com
In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

[HTML][HTML] A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

Z Yao, CTJ van Velthoven, M Kunst, M Zhang… - Nature, 2023 - nature.com
The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …

A multimodal cell census and atlas of the mammalian primary motor cortex

Principal manuscript editors, Analysis coordination… - Nature, 2021 - nature.com
Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …

Morphological diversity of single neurons in molecularly defined cell types

H Peng, P Xie, L Liu, X Kuang, Y Wang, L Qu, H Gong… - Nature, 2021 - nature.com
Dendritic and axonal morphology reflects the input and output of neurons and is a defining
feature of neuronal types,, yet our knowledge of its diversity remains limited. Here, to …

Single-neuron projectome of mouse prefrontal cortex

L Gao, S Liu, L Gou, Y Hu, Y Liu, L Deng, D Ma… - Nature …, 2022 - nature.com
Prefrontal cortex (PFC) is the cognitive center that integrates and regulates global brain
activity. However, the whole-brain organization of PFC axon projections remains poorly …

The Allen mouse brain common coordinate framework: a 3D reference atlas

Q Wang, SL Ding, Y Li, J Royall, D Feng, P Lesnar… - Cell, 2020 - cell.com
Recent large-scale collaborations are generating major surveys of cell types and
connections in the mouse brain, collecting large amounts of data across modalities, spatial …

[HTML][HTML] Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells

NW Gouwens, SA Sorensen, F Baftizadeh, A Budzillo… - Cell, 2020 - cell.com
Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …

[HTML][HTML] A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation

Z Yao, CTJ Van Velthoven, TN Nguyen, J Goldy… - Cell, 2021 - cell.com
The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in
perception, cognition, emotion, and learning. We profiled∼ 1.3 million cells covering the …

A positively tuned voltage indicator for extended electrical recordings in the brain

SW Evans, DQ Shi, M Chavarha, MH Plitt, J Taxidis… - Nature …, 2023 - nature.com
Genetically encoded voltage indicators (GEVIs) enable optical recording of electrical signals
in the brain, providing subthreshold sensitivity and temporal resolution not possible with …