Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

The recent development of machine learning methods to identify peptides in complex mass
spectrometric data constitutes a major breakthrough in proteomics. Longstanding methods …

Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …

For over a century, the importance of lipid metabolism in biology was recognized but difficult
to mechanistically understand due to the lack of sensitive and robust technologies for …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

Mass spectrometry is a central technology in the life sciences, providing our most
comprehensive account of the molecular inventory of the cell. In parallel with developments …

We report the progress on an electron-activated dissociation (EAD) device coupled to a
quadrupole TOF mass spectrometer (QqTOF MS) developed in our group. This device …

Metabolomics and lipidomics are new drivers of the omics era as molecular signatures and
selected analytes allow phenotypic characterization and serve as biomarkers, respectively …

Covering: up to 2021 Plants and their associated microbial communities are known to
produce millions of metabolites, a majority of which are still not characterized and are …