The number of animals used in research has increased with the advancement of research
and development in medical technology. Every year, millions of experimental animals are …

The discovery and development of any given drug is invariably a lengthy and expensive
process in the pharmaceutical industry. It starts with the identification and validation of the …

Caenorhabditis elegans has been proven to be a useful model organism for investigating
molecular and cellular aspects of numerous human diseases. More recently, investigators …

Antimicrobial resistance is an exigent public health concern owing to the emergence of
novel strains of human resistant pathogens and the concurrent rise in multi-drug resistance …

Current high‐throughput screening methods for drug discovery rely on the existence of
targets. Moreover, most of the hits generated during screenings turn out to be invalid after …

Hindered penetration of antibiotics through biofilms is one of the reasons for the alarming
increase in bacterial tolerance to antibiotics. Here, we investigate the potential of laser …

We present a lens-free optical tomographic microscope, which enables imaging a large
volume of approximately 15 mm3 on a chip, with a spatial resolution of< 1 μm×< 1 μm×< 3 …

Background Caenorhabditis elegans locomotion is a simple behavior that has been widely
used to dissect genetic components of behavior, synaptic transmission, and muscle function …

There is a well-defined regulatory framework governing the approval of chemicals for use as
pharmaceuticals or release into the environment. Toxicity assessment is thus a major hurdle …

Abstract Characterization of the in vivo behavior of nanomaterials aims to optimize their
design, to determine their biological effects, and to validate their application. The …