The helicates—chiral assemblies of two or more metal atoms linked by short or relatively
rigid multidentate organic ligands—may be regarded as non-peptide mimetics of α-helices …

We present a toolbox for high-throughput screening of image-based Caenorhabditis
elegans phenotypes. The image analysis algorithms measure morphological phenotypes in …

Increased Tau protein amyloidogenicity has been causatively implicated in several
neurodegenerative diseases, collectively called tauopathies. In pathological conditions, Tau …

The National Research Council has outlined the need for non-mammalian toxicological
models to test the potential health effects of a large number of chemicals while also reducing …

The development of preclinical models amenable to live animal bioactive compound
screening is an attractive approach to discovering effective pharmacological therapies for …

Next generation drug screening could benefit greatly from in vivo studies, using small animal
models such as Caenorhabditis elegans for hit identification and lead optimization. Current …

Caenorhabditis elegans is an instrumental research model used to advance our knowledge
in areas including development, metabolism, and aging. However, research on metabolism …

Invertebrate animals have been used as medicinals for 4,000 years and have served as
models for research and teaching since the late 1800s. Interest in invertebrate models has …

The nematode (worm) Caenorhabditis elegans is one of the most widely studied organisms
for biomedical research. Currently, C. elegans assays are performed either on petri dishes …

Bacterial biofilms are surface-attached communities of microorganisms that are protected by
an extracellular matrix of biomolecules. In the biofilm state, bacteria are significantly more …