As early as the 1920s, and subsequently in the 1959 Build and Blood Pressure Study (S1. 5-
1) of almost 5 million adults insured between 1934 and 1954, a strong direct relationship …

Background Beta‐blockers refer to a mixed group of drugs with diverse pharmacodynamic
and pharmacokinetic properties. They have shown long‐term beneficial effects on mortality …

Highlights•This review highlights development of JNC guidelines for the treatment of
hypertension from JNC 1, published in 1977, to JNC 8, published in 2014.•The review …

The present survey concentrates on pharmacodynamics and pharmacokinetics of selected β-
adrenergic blockers from the point of view of their stereochemistry. It could be shown that the …

In this paper, a novel and highly sensitive atenolol sensor based on a poly-dopamine (PDA)
is presented. PDA has been synthesized using a facile electro-deposition method. The …

BACKGROUND New evidence suggests that central systolic blood pressure (cSBP) and
augmentation index (AI) are superior predictors of adverse cardiovascular outcomes …

Introduction The prevalence of chronic hypertension is increasing in pregnant women. Beta-
blockers are among the most prevalent anti-hypertensive agents used in early pregnancy …

Glioblastoma is a brain neoplasm with limited 5‐year survival rates. Developments of new
treatment regimens that improve patient survival in patients with glioblastoma are needed. It …

There are currently three generations of beta-adrenergic blockers for the treatment of
hypertension and cardiovascular diseases. The 1st generation caused vasoconstriction and …

A new green route is proposed for the synthesis of enantiopure atenolol (a β1-blocker). An
enzymatic kinetic resolution approach was used to synthesize the enantiopure intermediates …