The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

Gender differences are present in many diseases and are especially prevalent in
cardiovascular disease. Males tend to suffer from myocardial infarctions earlier than …

The most common form of genetic heart disease is hypertrophic cardiomyopathy (HCM),
which is caused by variants in cardiac sarcomeric genes and leads to abnormal heart …

Rationale: Pyroptosis is a morphologically and mechanistically distinct form of cell death and
is characterized by GSDMD (gasdermin D) or GSDME (gasdermin E)-mediated necrosis …

Skeletal muscle health is a strong predictor of overall health and longevity. Pathologies
affecting skeletal muscle such as cancer cachexia, intensive care unit treatment, muscular …

Cardiovascular Diseases (CVDs) are the leading cause of death globally. More than 17
million people die worldwide from CVD per year. There is considerable evidence suggesting …

Myocardial infarct size is a major determinant of prognosis. Ischaemic preconditioning with
brief coronary occlusion and reperfusion before a sustained period of coronary occlusion …

Estrogen has pleiotropic effects on the cardiovascular system. The mechanisms by which
estrogen confers these pleiotropic effects are undergoing active investigation. Until a …

Well over 2 decades have passed since the endothelium-derived relaxation factor was
reported to be the gaseous molecule nitric oxide (NO). Although soluble guanylyl cyclase …

Fibrotic remodeling of the heart in response to injury contributes to heart failure, yet
therapies to treat fibrosis remain elusive. Yes-associated protein (YAP) is activated in …