Contribution of semen to early embryo development: fertilization and beyond

M Vallet-Buisan, R Mecca, C Jones… - Human …, 2023 - academic.oup.com
BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

[HTML][HTML] Contemporary use of ICSI and epigenetic risks to future generations

R Sciorio, SC Esteves - Journal of Clinical Medicine, 2022 - mdpi.com
Since the birth of Louise Brown in 1978 via IVF, reproductive specialists have acquired
enormous knowledge and refined several procedures, which are nowadays applied in …

[HTML][HTML] The role of long non-coding RNA H19 in infertility

Y Peng, R Guo, B Shi, D Li - Cell Death Discovery, 2023 - nature.com
Infertility is defined as the failure to conceive after at least one year of unprotected
intercourse. Long non-coding RNAs (lncRNAs) are transcripts that contain more than 200 …

Risk of genetic and epigenetic alteration in children conceived following ART: Is it time to return to nature whenever possible?

R Sciorio, L Tramontano, E Rapalini… - Clinical …, 2023 - Wiley Online Library
Assisted reproductive technology may influence epigenetic signature as the procedures
coincide with the extensive epigenetic modification occurring from fertilization to embryo …

[HTML][HTML] A DNA methylation perspective on infertility

G Shacfe, R Turko, HH Syed, I Masoud, Y Tahmaz… - Genes, 2023 - mdpi.com
Infertility affects a significant number of couples worldwide and its incidence is increasing.
While assisted reproductive technologies (ART) have revolutionized the treatment …

Are epigenetic mechanisms and nutrition effective in male and female infertility?

K Erdoğan, NT Sanlier, N Sanlier - Journal of nutritional science, 2023 - cambridge.org
This review discusses epigenetic mechanisms and the relationship of infertility in men and
women in relation to parameters pertaining to nutrition. The prevalence of infertility …

[HTML][HTML] Novel aspects of cAMP-response element modulator (CREM) role in spermatogenesis and male fertility

DE Sánchez-Jasso, SF López-Guzmán… - International Journal of …, 2023 - mdpi.com
Spermatogenesis is a very complex process with an intricate transcriptional regulation. The
transition from the diploid to the haploid state requires the involvement of specialized genes …

[HTML][HTML] Poor semen parameters are associated with abnormal methylation of imprinted genes in sperm DNA

B Song, Y Chen, C Wang, G Li, Z Wei, X He… - Reproductive Biology …, 2022 - Springer
Background Altered sperm DNA methylation patterns of imprinted genes as well as certain
spermatogenesis-related genes has been proposed as a possible mechanism of male …

Experimental Varicocele Impairs DNA Methylation and Demethylation in Germ Cells, TESE, and Epididymal Spermatozoa, Impacting Active DNA Demethylation in …

S Moshari, M Razi, MH Nasr-Esfahani, M Tavalaee… - Reproductive …, 2024 - Springer
Varicocele causes infertility. The current study has investigated the impact of experimental
varicocele on DNA methylation, demethylation, and damage in the germ cells, TESE-derived …

Ultra‐Rapid Freezing and Rapid Freezing Methods in Clinical ICSI Program: Effects on Sperm Biological Characteristics, DNA Methylation Stability, DNA …

M Zohrabi, MA Khalili, E Mangoli, F Zare… - Andrologia, 2024 - Wiley Online Library
The purpose of this study was to evaluate the differences in sperm function and embryo
morphokinetics following sperm cryopreservation by ultra‐rapid freezing or rapid freezing …