The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
Q Ning, D Wu, X Wang, D Xi, T Chen, G Chen… - Signal transduction and …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …
The role of epithelial damage in the pulmonary immune response
Pulmonary epithelial cells are widely considered to be the first line of defence in the lung
and are responsible for coordinating the innate immune response to injury and subsequent …
and are responsible for coordinating the innate immune response to injury and subsequent …
Tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine: An open-label partially-randomised ascending dose phase I …
Background Intranasal vaccination may induce protective local and systemic immune
responses against respiratory pathogens. A number of intranasal SARS-CoV-2 vaccine …
responses against respiratory pathogens. A number of intranasal SARS-CoV-2 vaccine …
The altered entry pathway and antigenic distance of the SARS-CoV-2 Omicron variant map to separate domains of spike protein
TP Peacock, JC Brown, J Zhou, N Thakur, K Sukhova… - biorxiv, 2022 - biorxiv.org
At the end of 2021 a new SARS-CoV-2 variant, Omicron, emerged and quickly spread
across the world. It has been demonstrated that Omicron's high number of Spike mutations …
across the world. It has been demonstrated that Omicron's high number of Spike mutations …
Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants
The high transmissibility of SARS-CoV-2 Omicron subvariants was generally ascribed to
immune escape. It remained unclear whether the emerging variants have gradually …
immune escape. It remained unclear whether the emerging variants have gradually …
Viral emissions into the air and environment after SARS-CoV-2 human challenge: a phase 1, open label, first-in-human study
J Zhou, A Singanayagam, N Goonawardane… - The Lancet …, 2023 - thelancet.com
Background Effectively implementing strategies to curb SARS-CoV-2 transmission requires
understanding who is contagious and when. Although viral load on upper respiratory swabs …
understanding who is contagious and when. Although viral load on upper respiratory swabs …
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection
VN Hariharan, M Shin, CW Chang… - Proceedings of the …, 2023 - National Acad Sciences
The continuous evolution of SARS-CoV-2 variants complicates efforts to combat the ongoing
pandemic, underscoring the need for a dynamic platform for the rapid development of pan …
pandemic, underscoring the need for a dynamic platform for the rapid development of pan …
Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19
X Li, Z Zhang, Z Wang… - Signal transduction and …, 2022 - nature.com
The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has dramatically influenced …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has dramatically influenced …
Systems analysis shows that thermodynamic physiological and pharmacological fundamentals drive COVID‐19 and response to treatment
RJ Head, ER Lumbers, B Jarrott… - Pharmacology …, 2022 - Wiley Online Library
Why a systems analysis view of this pandemic? The current pandemic has inflicted almost
unimaginable grief, sorrow, loss, and terror at a global scale. One of the great ironies with …
unimaginable grief, sorrow, loss, and terror at a global scale. One of the great ironies with …
Interferon‐induced transmembrane protein 3 (IFITM3) limits lethality of SARS‐CoV‐2 in mice
AD Kenney, A Zani, J Kawahara, AC Eddy, XL Wang… - EMBO …, 2023 - embopress.org
Interferon‐induced transmembrane protein 3 (IFITM3) is an antiviral protein that alters cell
membranes to block fusion of viruses. Conflicting reports identified opposing effects of …
membranes to block fusion of viruses. Conflicting reports identified opposing effects of …