Sterilising immunity that blocks infection for life, and thus prevents illness after infection, is
the ultimate goal for vaccines. Neither influenza infection nor vaccination provide sterilising …

Influenza is a respiratory disease caused by the influenza virus, which is highly
transmissible in humans. This paper presents a systematic review and meta-analysis of …

Based on data from 3,636 children, adolescents, and adults with acute respiratory infection
during October 4, 2021–February 12, 2022, seasonal influenza vaccination did not reduce …

Background Predominance of 2 antigenically drifted influenza viruses during the 2019–2020
season offered an opportunity to assess vaccine effectiveness against life-threatening …

The powerful immune responses elicited by the mRNA vaccines targeting the SARS-CoV-2
Spike protein contribute to their high efficacy. Yet, their efficacy can vary greatly between …

Seasonal influenza virus vaccines are effective when they are well matched to circulating
strains. Because of antigenic drift/change in the immunodominant hemagglutinin (HA) head …

On November 10, 2021, the Michigan Department of Health and Human Services (MDHHS)
was notified of a rapid increase in influenza A (H3N2) cases by the University Health Service …

Background Relative vaccine effectiveness (rVE) are metrics commonly reported to compare
absolute VE (aVE) of 2 vaccine products. Methods Estimates of rVE for enhanced influenza …

Egg-adaptive mutations in influenza hemagglutinin (HA) often emerge during the production
of egg-based seasonal influenza vaccines, which contribute to the largest share in the …

Abstract Objective Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate
globally, infecting humans and causing widespread morbidity and mortality. Here, we …