Mesenchymal stem cells (mesenchymal stromal cells, MSC) are multipotent stem cells that
can differentiate into cells of at least three mesodermal lineages, namely adipocytes …

Histone lysine crotonylation was first identified as a new type of post-translational
modification in 2011. In recent years, prominent progress has been made in the study of …

The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac
structure and contraction. However, the mechanism regulating this interaction in normal and …

The reversible acetylation of histone lysine residues is controlled by the action of
acetyltransferases and deacetylases (HDACs), which regulate chromatin structure and gene …

Homologous recombination (HR) during early oogenesis repairs programmed double-
strand breaks (DSBs) to ensure female fertility and offspring health. The exposure of fetal …

Common fragile sites (CFSs) are regions prone to chromosomal rearrangements, thereby
contributing to tumorigenesis. Under replication stress (RS), CFSs often harbor under …

The DNA damage response (DDR) system plays an important role in maintaining genome
stability and preventing related diseases. The DDR network comprises many proteins and …

DNA damage caused by internal or external factors lead to increased genomic instability
and various diseases. The DNA damage response (DDR) is a crucial mechanism that …

Background DNA double-strand break (DSB) induction and repair are important events for
determining cell survival and the outcome of cancer radiotherapy. The DNA-dependent …

Following a DNA double strand break (DSB), several nucleases and helicases coordinate to
generate single-stranded DNA (ssDNA) with 3′ free ends, facilitating precise DNA repair by …