Sugarcane bagasse is an agricultural residue rich in xylose, which may be used as a
feedstock for the production of high-value-added chemicals, such as xylonic acid, an organic …

Microbial consortia constitute a promising tool for achieving high‐value chemical bio‐
production. However, customizing the consortium ratio remains challenging. Herein, an …

In recent years, the development of green energy to replace fossil fuels has been the focus
of research. Higher alcohols are important biofuels and chemicals. The production of higher …

3, 4-Dihydroxybutyric acid (3, 4-DHBA) is an important platform chemical with versatile
applications. Traditional chemical approaches for 3, 4-DHBA production involving …

Poly-2-hydrobutanedioic acid (P2HBD), produced by the yeast-like fungus Aureobasidium
pullulans, is a new type of water-soluble polyhydroxy acid with potential applications in the …

Abstract Cis-3-hydroxypipecolic acid (cis-3-HyPip) is the crucial part of many alkaloids and
drugs. However, its bio-based industrial production remains challenging. Here, lysine …

Methyluridine (5-MU) is a prominent intermediate for industrial synthesis of several antiviral-
drugs, however, its availability over the past decades has overwhelmingly relied on …

Highlights•Growth-coupling design contributes releasing a metabolic bottleneck.•Coupling
growth and production inhibits the generation of nonproducing cells.•Two-stage culture …

Highlights•Feedback control can mitigate the impact of the ribosomal cost.•Feedback control
alleviates metabolic burden caused by engineered metabolic pathways.•Metabolic switch …

代谢调控是构建微生物细胞工厂的重要技术手段. 随着合成生物学技术的不断突破,
挖掘和人工设计的高质量调控元件大幅度提升了对细胞代谢网络的改造能力; …