[HTML][HTML] Discovery, development, and patent trends on molnupiravir: a prospective oral treatment for COVID-19
The COVID-19 pandemic needs no introduction at present. Only a few treatments are
available for this disease, including remdesivir and favipiravir. Accordingly, the …
available for this disease, including remdesivir and favipiravir. Accordingly, the …
Bench-to-bedside: Innovation of small molecule anti-SARS-CoV-2 drugs in China
L Yang, Z Wang - European journal of medicinal chemistry, 2023 - Elsevier
The ongoing COVID-19 pandemic has resulted in millions of deaths globally, highlighting
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …
the need to develop potent prophylactic and therapeutic strategies against SARS-CoV-2 …
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L
The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …
An updated review of computer‐aided drug design and its application to COVID‐19
The recent outbreak of the deadly coronavirus disease 19 (COVID‐19) pandemic poses
serious health concerns around the world. The lack of approved drugs or vaccines continues …
serious health concerns around the world. The lack of approved drugs or vaccines continues …
[HTML][HTML] Evolutionary trajectory of SARS-CoV-2 and emerging variants
The emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 …
(SARS-CoV-2), and more recently, the independent evolution of multiple SARS-CoV-2 …
[HTML][HTML] Small molecules in the treatment of COVID-19
S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
[HTML][HTML] Oral GS-441524 derivatives: Next-generation inhibitors of SARS‐CoV‐2 RNA‐dependent RNA polymerase
Z Wang, L Yang, X Song - Frontiers in immunology, 2022 - frontiersin.org
GS-441524, an RNA‐dependent RNA polymerase (RdRp) inhibitor, is a 1′-CN-substituted
adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral …
adenine C-nucleoside analog with broad-spectrum antiviral activity. However, the low oral …
SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19
ABSTRACT Introduction: The current SARS-CoV-2 pandemic urgently demands for both
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …
[HTML][HTML] The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
Q Ning, D Wu, X Wang, D Xi, T Chen, G Chen… - Signal transduction and …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …
[HTML][HTML] A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase
J Zhao, SS Guo, D Yi, Q Li, L Ma, Y Zhang, J Wang… - Antiviral research, 2021 - Elsevier
Antiviral therapeutics is one effective avenue to control and end this devastating COVID-19
pandemic. The viral RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 has been …
pandemic. The viral RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 has been …