Malaria in gold miners in the Guianas and the Amazon: current knowledge and challenges

M Douine, Y Lambert, L Musset, H Hiwat… - Current Tropical …, 2020 - Springer
Abstract Purpose of Review Following Paraguay and Argentina, several countries from the
Amazon region aim to eliminate malaria. To achieve this, all key affected and vulnerable …

Ecology, evolution, and epidemiology of zoonotic and vector-borne infectious diseases in French Guiana: Transdisciplinarity does matter to tackle new emerging …

B de Thoisy, O Duron, L Epelboin, L Musset… - Infection, Genetics and …, 2021 - Elsevier
Abstract French Guiana is a European ultraperipheric region located on the northern Atlantic
coast of South America. It constitutes an important forested region for biological conservation …

Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

LC Mathieu, H Cox, AM Early, S Mok, Y Lazrek… - Elife, 2020 - elifesciences.org
Antimalarial drug resistance has historically arisen through convergent de novo mutations in
Plasmodium falciparum parasite populations in Southeast Asia and South America. For the …

Self-diagnosis and self-treatment of malaria in hard-to-reach and mobile populations of the Amazon: results of Malakit, an international multicentric intervention …

M Douine, Y Lambert, MS Galindo, L Mutricy… - The Lancet Regional …, 2021 - thelancet.com
abstract Background: Illegal gold miners are currently key hosts for malaria in French
Guiana (FG), with a risk of emergence of resistance linked to improper use of artemisinin …

Zoonoses and gold mining: A cross-sectional study to assess yellow fever immunization, Q fever, leptospirosis and leishmaniasis among the population working on …

M Douine, T Bonifay, Y Lambert, L Mutricy… - PLOS Neglected …, 2022 - journals.plos.org
Background Most emerging pathogens are zoonoses and have a wildlife origin.
Anthropization and disruption of ecosystems favor the crossing of inter-species barriers. We …

Plasmodium falciparum Artemisinin Resistance: The Effect of Heme, Protein Damage, and Parasite Cell Stress Response

MR Rosenthal, CL Ng - ACS infectious diseases, 2020 - ACS Publications
Despite a significant decline in morbidity and mortality over the last two decades, in 2018
there were 228 million reported cases of malaria and 405000 malaria-related deaths …

Impact of piperaquine resistance in Plasmodium falciparum on malaria treatment effectiveness in The Guianas: a descriptive epidemiological study

C Florimond, F de Laval, AM Early… - The Lancet Infectious …, 2024 - thelancet.com
Background Plasmodium falciparum is an apicomplexan parasite responsible for lethal
cases of malaria. According to WHO recommendations, P falciparum cases are treated with …

Perceptions about malaria among Brazilian gold miners in an Amazonian border area: perspectives for malaria elimination strategies

FLG Murta, LLG Marques, APC Santos, TSB Batista… - Malaria Journal, 2021 - Springer
Abstract Background Mining in the Amazon exposes gold miners to various diseases,
including malaria, whose control is still a major challenge. The environment of the mines …

From an interventional study to a national scale-up: lessons learned from the Malakit strategy at the French Guiana–Suriname border

M Douine, H Cairo, MS Galindo, S Vreden, Y Lambert… - Malaria Journal, 2023 - Springer
Scaling-up an experimental intervention is always a challenge. On the border between
French Guiana, Brazil and Suriname, an interventional study demonstrated the effectiveness …

Malakit: an innovative pilot project to self-diagnose and self-treat malaria among illegal gold miners in the Guiana Shield

M Douine, A Sanna, M Galindo, L Musset… - Malaria journal, 2018 - Springer
Background Illegal gold miners in French Guiana, a French overseas territory
('département') located in Amazonia, often carry malaria parasites (up to 46.8%). While the …