Pathophysiology of COVID-19-associated acute kidney injury
Although respiratory failure and hypoxaemia are the main manifestations of COVID-19,
kidney involvement is also common. Available evidence supports a number of potential …
kidney involvement is also common. Available evidence supports a number of potential …
Can activation of NRF2 be a strategy against COVID-19?
A Cuadrado, M Pajares, C Benito… - Trends in …, 2020 - cell.com
Acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 is largely the result of
a dysregulated host response, followed by damage to alveolar cells and lung fibrosis …
a dysregulated host response, followed by damage to alveolar cells and lung fibrosis …
Effect of discontinuing vs continuing angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on days alive and out of the hospital in patients …
Importance It is unknown whether angiotensin-converting enzyme inhibitors (ACEIs) or
angiotensin II receptor blockers (ARBs) have a positive, neutral, or negative effect on clinical …
angiotensin II receptor blockers (ARBs) have a positive, neutral, or negative effect on clinical …
Continuation versus discontinuation of renin–angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial
Background Biological considerations suggest that renin–angiotensin system inhibitors
might influence the severity of COVID-19. We aimed to evaluate whether continuing versus …
might influence the severity of COVID-19. We aimed to evaluate whether continuing versus …
Heart failure in COVID‐19 patients: prevalence, incidence and prognostic implications
JR Rey, J Caro‐Codón, SO Rosillo… - European journal of …, 2020 - Wiley Online Library
Aims Data on the impact of COVID‐19 in chronic heart failure (CHF) patients and its
potential to trigger acute heart failure (AHF) are lacking. The aim of this work was to study …
potential to trigger acute heart failure (AHF) are lacking. The aim of this work was to study …
Can SARS-CoV-2 virus use multiple receptors to enter host cells?
LK Gadanec, KR McSweeney, T Qaradakhi… - International journal of …, 2021 - mdpi.com
The occurrence of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-
2), responsible for coronavirus disease 2019 (COVD-19), represents a catastrophic threat to …
2), responsible for coronavirus disease 2019 (COVD-19), represents a catastrophic threat to …
Circadian rhythms, disease and chronotherapy
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …
DPP4 and ACE2 in diabetes and COVID-19: therapeutic targets for cardiovascular complications?
I Valencia, C Peiro, O Lorenzo… - Frontiers in …, 2020 - frontiersin.org
COVID-19 outbreak, caused by severe acute respiratory syndrome (SARS)-CoV-2
coronavirus has become an urgent health and economic challenge. Diabetes is a risk factor …
coronavirus has become an urgent health and economic challenge. Diabetes is a risk factor …
Angiotensin-converting enzyme 2 (ACE2) expression increases with age in patients requiring mechanical ventilation
SA Baker, S Kwok, GJ Berry, TJ Montine - PLoS One, 2021 - journals.plos.org
Mortality due to Covid-19 is highly associated with advanced age, owing in large part to
severe lower respiratory tract infection. SARS-CoV-2 utilizes the host ACE2 receptor for …
severe lower respiratory tract infection. SARS-CoV-2 utilizes the host ACE2 receptor for …
A review of human coronaviruses' receptors: the host-cell targets for the crown bearing viruses
A novel human coronavirus prompted considerable worry at the end of the year 2019. Now,
it represents a significant global health and economic burden. The newly emerged …
it represents a significant global health and economic burden. The newly emerged …