Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Life expectancy is increasing worldwide, with a resultant increase in the elderly population.
Aging is characterized by the progressive loss of skeletal muscle mass and strength–a …

The slow and continuous loss of muscle mass that progresses with aging is defined as
“sarcopenia”. Sarcopenia represents an important public health problem, being closely …

Background A sarcopenia diagnosis is confirmed by the presence of low muscle quantity or
quality under the 2018 revised definition by the European Working Group on Sarcopenia in …

The type 2 immune response controls helminth infection and maintains tissue homeostasis
but can lead to allergy and fibrosis if not adequately regulated. We have discovered local …

Frailty is a functional term that describes a decline in physiological functions that leads to
dependency, vulnerability to stressors, high risk for adverse health outcomes, increased risk …

Complement is an important effector mechanism for antibody-mediated clearance of
infections and tumor cells. Upon binding to target cells, the antibody's constant (Fc) domain …

C1q is the recognition molecule of the classical pathway of the complement system. By
binding to its targets, such as antigen-bound immunoglobulins or C-reactive protein, C1q …

Complement component C1q plays an important recognition role in adaptive, and innate,
immunity through its ability to interact, via its six globular head regions, with both …

The importance of the complement component C1q has been highlighted by its involvement
in autoimmunity, infection, inflammatory diseases, and tumors. The unique tulip-like structure …