[HTML][HTML] Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
YL Wu, ZJ Lin, CC Li, X Lin, SK Shan, B Guo… - … and Targeted Therapy, 2023 - nature.com
Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
[HTML][HTML] Epigenetics in human obesity and type 2 diabetes
Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …
[HTML][HTML] Recent progress in epigenetics of obesity
FY Wu, RX Yin - Diabetology & Metabolic Syndrome, 2022 - Springer
Nowadays, obesity is one of the largest public health problems worldwide. In the last few
decades, there has been a marked increase in the obesity epidemic and its related …
decades, there has been a marked increase in the obesity epidemic and its related …
[HTML][HTML] The applied implications of epigenetics in anxiety, affective and stress-related disorders-A review and synthesis on psychosocial stress, psychotherapy and …
MA Schiele, MG Gottschalk, K Domschke - Clinical psychology review, 2020 - Elsevier
Mental disorders are highly complex and multifactorial in origin, comprising an elaborate
interplay of genetic and environmental factors. Epigenetic mechanisms such as DNA …
interplay of genetic and environmental factors. Epigenetic mechanisms such as DNA …
[HTML][HTML] Genetics, epigenetics and transgenerational transmission of obesity in children
N Panera, C Mandato, A Crudele… - Frontiers in …, 2022 - frontiersin.org
Sedentary lifestyle and consumption of high-calorie foods have caused a relentless increase
of overweight and obesity prevalence at all ages. Its presently epidemic proportion is …
of overweight and obesity prevalence at all ages. Its presently epidemic proportion is …
Association of cardiovascular health through young adulthood with genome-wide DNA methylation patterns in midlife: the CARDIA study
Background: Cardiovascular health (CVH) from young adulthood is strongly associated with
an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining …
an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining …
[HTML][HTML] Independent phenotypic plasticity axes define distinct obesity sub-types
Studies in genetically 'identical'individuals indicate that as much as 50% of complex trait
variation cannot be traced to genetics or to the environment. The mechanisms that generate …
variation cannot be traced to genetics or to the environment. The mechanisms that generate …
The potential of DNA methylation as a biomarker for obesity and smoking
A Heikkinen, S Bollepalli… - Journal of internal …, 2022 - Wiley Online Library
DNA methylation is an epigenetic modification that has consistently been shown to be linked
with a variety of human traits and diseases. Because DNA methylation is dynamic and …
with a variety of human traits and diseases. Because DNA methylation is dynamic and …
[HTML][HTML] Omics biomarkers in obesity: novel etiological insights and targets for precision prevention
K Aleksandrova, C Egea Rodrigues, A Floegel… - Current obesity …, 2020 - Springer
Abstract Purpose of Review Omics-based technologies were suggested to provide an
advanced understanding of obesity etiology and its metabolic consequences. This review …
advanced understanding of obesity etiology and its metabolic consequences. This review …
Body mass index drives changes in DNA methylation: a longitudinal study
Rationale: Previous EWASs (Epigenome-Wide Association Studies) suggest that obesity
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …