Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors with high prevalence
among adult populations and elevated costs for public health systems worldwide. Despite …

The coordinated regulation between cellular glucose uptake and endogenous glucose
production is indispensable for the maintenance of constant blood glucose concentrations …

Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

Background Elevated lipids in umbilical cord blood affect fetal programming, leading to a
higher risk of developing cardiovascular disease in later life. However, the causes of …

Sterol Regulatory Element Binding Protein-1c is a transcription factor that controls the
synthesis of lipids from glucose in the liver, a process which is of utmost importance for the …

Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological change characterized by
the accumulation of triglycerides in hepatocytes and has frequently been associated with …

The worldwide rising prevalence of obesity and insulin resistance is associated with a
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with
significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and …

The metabolic syndrome is a common metabolic disorder that results from the increasing
prevalence of obesity. The disorder is defined in various ways, but in the near future a new …

Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC
kinase family members, including Akt, SGK1, and PKC, in response to insulin/IGF1. The liver …