One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …

Genes involved in biological pathways are often collocalised in gene clusters, the
comparison of which can give valuable insights into their function and evolutionary history …

Genome mining has become a key technology to exploit natural product diversity. Although
initially performed on a single-genome basis, the process is now being scaled up to mine …

Societal Impact Statement Plants and fungi have provided, or inspired, key pharmaceuticals
for global health challenges, including cancer, heart disease, dementia, and malaria, and …

The rising prevalence of multidrug-resistant bacteria is an urgent health crisis that can only
be countered through renewed investment in the discovery and development of antibiotics …

Background Genome mining for biosynthetic gene clusters (BGCs) has become an integral
part of natural product discovery. The> 200,000 microbial genomes now publicly available …

Fungi are prolific producers of natural products, compounds which have had a large societal
impact as pharmaceuticals, mycotoxins, and agrochemicals. Despite the availability of over …

Section Flavi encompasses both harmful and beneficial Aspergillus species, such as
Aspergillus oryzae, used in food fermentation and enzyme production, and Aspergillus …

Aspergillus section Nigri comprises filamentous fungi relevant to biomedicine, bioenergy,
health, and biotechnology. To learn more about what genetically sets these species apart …