Oxidative stress and NRF2/KEAP1/ARE pathway in diabetic kidney disease (DKD): new perspectives

DM Tanase, EM Gosav, MI Anton, M Floria… - Biomolecules, 2022 - mdpi.com
Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with
increased prevalence and incidence. In addition to its macrovascular damage, through its …

A natural products solution to diabetic nephropathy therapy

Q Hu, L Jiang, Q Yan, J Zeng, X Ma, Y Zhao - Pharmacology & Therapeutics, 2023 - Elsevier
Diabetic nephropathy is one of the most common complications in diabetes. It has been
shown to be the leading cause of end-stage renal disease. However, due to their complex …

Health benefits and limitations of rutin-A natural flavonoid with high nutraceutical value

R Semwal, SK Joshi, RB Semwal, DK Semwal - Phytochemistry Letters, 2021 - Elsevier
Rutin, a plant-derived natural flavonoid, is considered among the top therapeutically active
phytochemicals and one of the major bioactive constituents of a variety of natural foods and …

Flavonoids on diabetic nephropathy: advances and therapeutic opportunities

Q Hu, C Qu, X Xiao, W Zhang, Y Jiang, Z Wu, D Song… - Chinese medicine, 2021 - Springer
With the advances in biomedical technologies, natural products have attracted substantial
public attention in the area of drug discovery. Flavonoids are a class of active natural …

Flavonoids in treatment of chronic kidney disease

YL Cao, JH Lin, HP Hammes, C Zhang - Molecules, 2022 - mdpi.com
Chronic kidney disease (CKD) is a progressive systemic disease, which changes the
function and structure of the kidneys irreversibly over months or years. The final common …

[HTML][HTML] Nrf2 signaling in diabetic nephropathy, cardiomyopathy and neuropathy: therapeutic targeting, challenges and future prospective

M Hashemi, MA Zandieh, S Ziaolhagh… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Western lifestyle contributes to an overt increase in the prevalence of metabolic anomalies
including diabetes mellitus (DM) and obesity. Prevalence of DM is rapidly growing …

Flavonoids improve type 2 diabetes mellitus and its complications: A review

X Yi, M Dong, N Guo, J Tian, P Lei, S Wang… - Frontiers in …, 2023 - frontiersin.org
The prevalence of type 2 diabetes mellitus (T2DM) is increasing every year. Medications are
currently the most common therapy for T2DM. However, these medications have certain …

Polyherbal mixture ameliorates hyperglycemia, hyperlipidemia and histopathological changes of pancreas, kidney and liver in a rat model of type 1 diabetes

V Madić, A Petrović, M Jušković, D Jugović… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance One of the commonly prescribed 'anti-diabetic'polyherbal
mixtures by European herbalists is made of Rubus fruticosus and Vaccinium myrtillus …

Rutin inhibits cardiac apoptosis and prevents sepsis-induced cardiomyopathy

XL Meng, MM Yu, YC Liu, YL Gao, XS Chen… - Frontiers in …, 2022 - frontiersin.org
Rutin is a flavanol-type polyphenol that consists of flavanol quercetin and the disaccharide
rutinose, which has been reported to exert various biological effects such as antioxidant and …

Antidiabetic effects of polyherbal mixture made of Centaurium erythraea, Cichorium intybus and Potentilla erecta

A Petrović, V Madić, G Stojanović, I Zlatanović… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance The polyherbal mixture made of Centaurium erythraea
aerial parts and Cichorium intybus roots and Potentilla erecta rhizomes has been used for …