It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in
older women result in higher rates of miscarriage with aneuploidy. Age-related decline in …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

Ovarian aging is a natural and physiological aging process characterized by loss of quantity
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …

Mitochondria play a vital role in embryo development. They are the principal site of energy
production and have various other critical cellular functions. Despite the importance of this …

It is well known that female reproduction ability decreases during the forth decade of life due
to age-related changes in oocyte quality and quantity; although the number of women trying …

BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

The manifestation of mitochondrial DNA (mtDNA) diseases depends on the frequency of
heteroplasmy (the presence of several alleles in an individual), yet its transmission across …

As women delay childbearing because of demographic and socioeconomic trends,
reproductive aging and ensuing ovarian dysfunction become increasingly more prevalent …