As an organ critically important for targeting and clearing viruses, bacteria, and other foreign
material, the liver operates via immune-tolerant, anti-inflammatory mechanisms …

The current test systems employed by pharmaceutical industry are poorly predictive for drug-
induced liver injury (DILI). The 'MIP-DILI'project addresses this situation by the development …

Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the
market. The use of nonclinically relevant in vitro and in vivo testing systems contributes to …

Introduction. Amiodarone has been used for more than 5 decades for the treatment of
various tachyarrhythmias and previously for the treatment of refractory angina. There are …

RATIONALE Several mechanisms have been anticipated for the toxicity of amiodarone, such
as oxidative stress, lipid peroxidation, phospholipidosis, free radical generation, etc …

Background: Amiodarone is associated with varying degrees of hepatotoxicity. Aims: to
study the association between the presence of the metabolic syndrome or rightsided heart …

Background Liver cirrhosis is an uncommon but not rare side effect of amiodarone-induced
hepatotoxicity. Patients with hepatitis B virus and hepatitis C virus infections are at a high …

Aims: The purpose of this study was to investigate the hepatoprotective effect of aqueous
and ethanolic extract of Crocus sativus in amiodarone-induced hepatotoxicity in rabbits …

Orlistat is a safe and effective drug to treat obesity by acting as a pancreatic and gastric
lipase inhibitor, resulting in reduction in fat absorption. There is also concern that it may be …

With the increasing prevalence of cardiovascular disease and associated disorders globally,
there has been a proliferation of medications for antiplatelet therapy, dyslipidemia, glycemic …