I would like to start by thanking my supervisors Professor Petri Kursula and Professor Clive
Bramham for allowing me to take on this project and guiding me along the way. Andrea …

With improvements in biophysical approaches, there is growing interest in characterizing
large, flexible multi-protein complexes. The use of recombinant baculoviruses to express …

Molecular chaperones are a class of oligomeric proteins that play a critical role inpreventing
the aggregation of non-native protein so that these proteins can later be refolded …

A robust study on the Ataxin-3 fibrillization pathway for the discovery of new inhibitory
compounds Francisco Rosário de Figuei Page 1 Francisco Rosário de Figueiredo .A robust …

As the rising of structural DNA nanotechnology, scaffolded DNA origami emerged earlier this
century. Development and application of this new technology has been surging due to its …

Abstract Cryogenic Electron Microscopy (Cryo-EM) is a method that can be used for studying
the structure of biological systems. Biological samples are frozen to cryogenic temperatures …

The radical-mediated thiol-ene addition reaction has been known for more than a century
and the most important application is in polymerization. However, thiol-ene step …

Myosin 5a (Myo5a) is responsible for transporting cellular cargos, such as the endoplasmic
reticulum, along filamentous actin (F-actin) to the periphery of cells. The lever has a key role …

Abstract The paramyxovirus Hendra henipavirus (HeV) is an emerging, zoonotic pathogen
with a high case-mortality rate and scant therapeutic interventions. Placed on the short list of …

Leptospirosis is one of the often-neglected fatal zoonotic diseases endemic to most
developing countries. The disease transmits mostly through contact of rodent urine …