The repair of DNA damage is a complex process that relies on particular pathways to
remedy specific types of damage to DNA. The range of insults to DNA includes small …

The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …

Neuroendocrine prostate cancer is a histological variant of prostate cancer that is
characterized by aggressiveness, poor clinical outcomes, and expression of neuroendocrine …

Recent findings indicate that a major mechanism by which poly (ADP-ribose) polymerase
(PARP) inhibitors kill cancer cells is by trapping PARP1 and PARP2 to the sites of DNA …

DNA damage response (DDR) deficiencies result in genome instability, which is one of the
hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various …

Among the earliest responses of mammalian cells to DNA damage is catalytic activation of a
nuclear enzyme poly (ADP-ribose) polymerase-1 (PARP-1). Activated PARP-1 forms the …

Poly [ADP-ribose] polymerase 1 (PARP-1) is a highly abundant chromatin-associated
enzyme. It catalyzes the NAD+-dependent polymerization of long chains of poly-ADP ribose …

PARP family members can be found spread across all domains and continue to be essential
molecules from lower to higher eukaryotes. Poly (ADP‐ribose) polymerase 1 (PARP‐1) …

Adenosine diphosphate (ADP)-ribosylation is an important posttranslational modification
catalyzed by a variety of enzymes, including poly (ADP ribose) polymerases (PARPs), which …

Poly (ADP-ribose) polymerase (PARP) inhibitors have demonstrated great promise for
treating cancers with homologous recombination (HR) defects, such as germline BRCA1/2 …