Humans rely on visual cues to navigate the world around them. Vision begins with the
detection of light by photoreceptor cells in the retina, a light-sensitive tissue located at the …

Retinopathy of prematurity is defined as retinal abnormalities that occur during development
as a consequence of disturbed oxygen conditions and nutrient supply after preterm birth …

Ocular hypertension during glaucoma can lead to hypoxia, activation of the HIF transcription
factors, and a metabolic shift toward glycolysis. This study aims to test whether chronic HIF …

Photoreceptors consume glucose supplied by the choriocapillaris to support
phototransduction and outer segment (OS) renewal. Reduced glucose supply underlies …

Cis-regulatory elements (CREs) play a critical role in the development and disease-states of
all human cell types. In the retina, CREs have been implicated in several inherited disorders …

The postmitotic retina is highly metabolic and the photoreceptors depend on aerobic
glycolysis for an energy source and cellular anabolic activities. Lactate dehydrogenase A …

Müller glia (MG), the principal glial cell of the retina, have a metabolism that defies
categorization into glycolytic versus oxidative. We showed that MG mount a strong hypoxia …

Retinal bipolar and amacrine cells receive visual information from photoreceptors and
participate in the first steps of image processing in the retina. Several studies have …

l-Serine (Ser) is synthesized de novo from 3-phosphoglycerate via the phosphorylated
pathway committed by phosphoglycerate dehydrogenase (Phgdh). A previous study …

The majority of inherited retinal degenerative diseases and dry age-related macular
degeneration are characterized by decay of the outer retina and photoreceptors, which …