The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

Functional polymeric micro-/nanofibers have emerged as promising materials for the
construction of structures potentially useful in biomedical fields. Among all kinds of …

Electrospinning is historically related to tissue engineering due to its ability to produce nano-
/microscale fibrous materials with mechanical and functional properties that are extremely …

Molecular mechanisms associated with human germ cell aplasia in infertile men remain
undefined. Here we perform single-cell transcriptome profiling to highlight differentially …

Peritoneal metastases (PM) are common routes of dissemination for colorectal cancer
(CRC) and remain a lethal disease with a poor prognosis. The properties of the extracellular …

Mechanomedicine is an emerging field focused on characterizing mechanical changes in
cells and tissues coupled with a specific disease. Understanding the mechanical cues that …

Breast cancer (BC) is the most common cancer and principal cause of death among females
worldwide. Invasion and metastasis are major causes which influence the survival and …

Atomic Force Microscopy (AFM) is successfully used for the quantitative investigation of the
cellular mechanosensing of the microenvironment. To this purpose, several force …

Three-dimensional tumor models have become established in both basic and clinical
research. As multicellular systems consisting of tumor and tumor-associated cells, they can …

Cancer immunotherapy with monoclonal antibodies directed against regulatory pathways in
T lymphocytes has been revolutionizing medical oncology, and the clinical success of …