TIGAR (TP53-induced glycolysis and apoptosis regulator) is the downstream target gene of
p53, contains a functional sequence similar to 6-phosphofructose kinase/fructose-2, 6 …

The ability of adult cardiomyocytes to regenerate is limited, and irreversible loss by cell
death plays a crucial role in heart diseases. Autophagy is an evolutionarily conserved …

Tripartite motif (TRIM) 31 has been implicated in diverse biological and pathological
conditions. However, whether TRIM31 plays a role in ischemic stroke progression is not …

Metabolic reprogramming in cancer cells is controlled by the activation of multiple oncogenic
signalling pathways in order to promote macromolecule biosynthesis during rapid …

Introduction: It has been known for over half a century that tumors exhibit an increased
demand for nutrients to fuel their rapid proliferation. Interest in targeting cancer metabolism …

Altered metabolic regulation has long been observed in human cancer and broadly used in
the clinic for tumor detection. Two recent findings—the direct regulation of metabolic …

TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis and increases
the flow of pentose phosphate pathway (PPP), which generates NADPH and pentose. We …

Altered metabolic phenotype has been recognized as a hallmark of tumor cells for many
years, but this aspect of the cancer phenotype has come into greater focus in recent years …

BACKGROUND & AIMS: Chronic ethanol consumption in the Long–Evans (LE) rat has been
associated with hepatic p53 activation, and inhibition of the insulin/PI3K/AKT signal …

Objective Loss of function mutations in PINK1 typically lead to early onset Parkinson disease
(PD). Zebrafish (Danio rerio) are emerging as a powerful new vertebrate model to study …